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(Hypertension. 2008;52:215.)
© 2008 American Heart Association, Inc.

Editorial Commentaries

Metalloproteinases Damage the Insulin Receptor to Cause Insulin Resistance in Spontaneously Hypertensive Rats

H. Glenn Bohlen

From the Department of Cellular and Integrative Physiology, Indiana University Medical School, Indianapolis.

Correspondence to H. Glenn Bohlen, Department of Cellular and Integrative Physiology, Indiana University Medical School, 635 Barnhill Dr, Indianapolis, IN 46202. E-mail gbohlen@iupui.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

The elegant study by Delano and Schmid-Schönbein¹ points to a potentially very important overlap of an insulin resistance mechanism with hypertension in the spontaneously hypertensive rat (SHR). Their investigation will likely be important to both the obese and hypertensive populations. With the national and international emphasis on obesity and its attendant cardiovascular problems, there is a tendency to forget that essential hypertension affects about the same percentage of humans as does serious obesity and an even higher percentage of the population than does type 2 diabetes mellitus. Obesity leading to insulin resistance and, in severe situations, type 2 diabetes mellitus, does have a genetic predisposition that the patient’s lifestyle can mitigate. However, hypertension even in the lean population has an established genetic basis and often develops despite every attempt to avoid inappropriate lifestyle issues. There is obviously an overlap of the obese and hypertensive genetic populations and likely a sharing of some mechanisms to cause many of their common vascular and cardiac pathologies.

The existence of insulin resistance in the SHR came to attention in 1988 by a study by Horl et al.² At the time, this seemed rather unusual, because the SHR is generally quite lean, and the dependence of insulin resistance on some degree of obesity was a common concept. In 1991, Reaven and Chang³ and Reaven⁴ questioned whether the insulin resistance leads to hypertension or vice versa in the SHR and hypertensive humans. The interest in hypertension and insulin resistance since 1988 has generated >200 articles dealing . . . [Full Text of this Article]

Related Article:

Proteinase Activity and Receptor Cleavage: Mechanism for Insulin Resistance in the Spontaneously Hypertensive Rat

Frank A. DeLano and Geert W. Schmid-Schönbein
Hypertension 2008 52: 415-423. [Abstract] [Full Text] [PDF]