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(Hypertension. 1997;29:b1.)
© 1997 American Heart Association, Inc.
Awards |
Hoechst Marion Roussel Hypertension Research Clinical Fellowship Award 1996
The purpose of this program and research award is to stimulate physicians-in-training to pursue a career in clinical research in hypertension. The research fellow must be conducting work in which he is the major senior investigator in any area of his choice including clinical or laboratory aspects of the hypertensive diseases. The fellow’s work would be supervised by the director of the research training program (the mentor), but the conduct of the investigation is primarily by the research fellow. The winning presentation receives $3,000 and the fellow’s mentor receives $25,000 to support the clinical investigative training of a research fellow the following year.
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The Council for High Blood Pressure Research of the American Heart Association is pleased to announce that Dr David B. Simon is the winner of the Twelfth Annual Hoechst Marion Roussel Hypertension Research Clinical Fellowship Award. He received his MD from the Albert Einstein College of Medicine in the Bronx, NY, in 1989 and completed his internship, residency, and chief residency at Yale New Haven Hospital in 1993. He recently completed his fellowship in the Division of Nephrology at the Yale University School of Medicine and currently is an Assistant Professor in the Section of Nephrology at Yale.
Dr Simon joined the laboratory of Dr Richard P. Lifton in 1994 with a particular interest in defining the molecular genetics of human blood pressure variation. His work has focused on autosomal recessive electrolyte disorders in which affected individuals suffer from hypokalemia, metabolic alkalosis, and hypotension due to salt wasting. He first described the molecular basis of the most common form of these disorders, Gitelman’s syndrome, in which affected individuals are also hypocalciuric and hypomagnesemic. He found that Gitelman’s syndrome is caused by inactivating mutations in the thiazide-sensitive sodium chloride cotransporter in the distal nephron of the kidney, NCCT, the target of thiazide diuretics.
In his abstract at the CHBPR meeting he reported the molecular basis of the other major cause of inherited hypokalemic alkalosis, Bartter’s syndrome, in which affected individuals have a neonatal presentation of severe volume depletion, failure to thrive, hypercalciuria, and nephrocalcinosis. He found that this disorder is caused by inactivating mutations in one of two genes: the renal sodium-potassium-2 chloride cotransporter, NKCC2 (the target of loop diuretics, eg, furosemide), or the renal potassium channel, ROMK.
These findings have greatly expanded the understanding of human blood pressure variation as well as the regulation of potassium, magnesium, and calcium handling by the kidney, enabling testing of whether the more common heterozygote carriers of mutations in these genes might be protected from the development of hypertension by these hypotensive alleles.
Previous Recipients of the Hoechst Marion Roussel Award
1995
JONI H. HANSSON
Yale University School of Medicine
Mentor: Richard Lifton
1994
JOHN KREGE, MD
University of North Carolina
Mentor: Oliver Smithies
1993
LUIS JUNCOS, MD
Henry Ford Hospital
Mentors: Sadayoski Ito and Oscar A. Carretero
1992
AMY L. TUCKER, MD
University of Virginia
Mentor: Kevin R. Lynch
1991
ELIZABETH GILBERT D’ANGELO, MD
University of Virginia
Mentor: Christopher M. Rembold
1990
BRUNO ESCALANTE, MD
New York Medical College
Mentor: John C. McGiff
1989
ALLEN EVERETT, MD
University of Virginia
Mentor: Ariel Gomez
1988
ALLEN J. NAFTILAN, MD
Harvard Medical School/Brigham and Women’s Hospital
Mentor: Victor J. Dzau
1987
CHRISTOPHER M. REMBOLD, MD
University of Virginia
Mentor: Carlos R. Ayers
1986
JUDITH E. KALINEJAK, MD, PHD
Stanford Medical Center
Mentor: Andrew J. Perlman
1985
GAIL K. ADLER, MD, PHD
Harvard Medical School/Peter Bent Brigham Hospital
Mentor: Gordon H. Williams
1984
CHRISTINE SEIDMAN, MBBS
Harvard Medical School/Massachusetts General Hospital
Mentor: Robert M. Graham
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