(Hypertension. 1997;29:b5.)
© 1997 American Heart Association, Inc.
Awards |
CIBA Award for Hypertension Research 1996
Dr Smithies received the CIBA Award for his groundbreaking work in the use of homologous recombination to insert altered genes into specified positions in the DNA of living cells and the application of this technique to transfer "designer mutations" to living animals and to the study of high blood pressure and cardiovascular diseases.
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Dr Smithies was born in Halifax, England, and received his DPhil in Biochemistry in 1951 at Oxford University. After 2 years as a post-doctoral fellow at the University of Wisconsin, he spent 6 years at the Connaught Medical Research Laboratory in Toronto, Ontario, where he invented the first high-resolution gel electrophoresis system. This technique led to his discovery of inherited differences in the serum proteins of normal individuals. Thereafter, he returned to Wisconsin as a geneticist. As the field progressed from studying proteins to cloning DNA, Dr Smithies changed to his present discipline of molecular genetics.
In 1985 Dr Smithies demonstrated for the first time that planned modifications to the genome could be made in living cells by means of homologous recombination (gene targeting). In 1987 he helped to show that gene targeting in mouse embryonic stem cells could be used to alter specific genes in the mouse genome leading to the subsequent production of "designer mice." One of the earliest mutants made in Dr Smithies’s laboratory, which is now at the University of North Carolina, provides a mouse model of cystic fibrosis.
Dr Smithies is a member of the US National Academy of Sciences, a past president of the Genetics Society of America, and twice recipient of a Gairdner Foundation Award: once in 1990 for gel electrophoresis and once in 1993 for gene targeting.
Past Recipients of the CIBA Award
1995
LOUIS J. IGNARRO, PHD
SALVADOR MONCADA, MD
1994
ADOLFO J. DEBOLD, OC, PHD, FRSC
ERVIN G. ERDöS, MD
1993
JOHN PAUL RAPP, DVM, PHD
1992
DETLEV GANTEN, MD, PHD
1991
SALOMON Z. LANGER, MD
ANDREW P. SOMLYO, MD
AVRIL V. SOMLYO, PHD
1990
FRANCOIS M. ABBOUND, MD
MICHAEL J. BRODY, PHD
1989
EDGAR HABER, MD
1988
ROBERT R. FURCHGOTT, PHD
FERID MURAD, MD, PHD
1987
DONALD J. REIS, MD
1986
MAURICE B. BURG, MD
JOHN C. MCGIFF, MD
E. ERIC MUIRHEAD, MD
1985
PIERRE CORVOL, MD
TADASHI INAGAMI, PHD
JOEL MENARD, MD
1984
DAVID F. BOHR, MD
1983
DAVID W. CUSHMAN, PHD
SERGIO HENRIQUE FERREIRA, MD, PHD
MIGUEL A. ONDETTI, PHD
1982
KYUZO AOKI, MD
KOZO OKAMOTO, MD
YUKIO YAMORI, MD
1981
EDWARD D. FREIS, MD
WILLIAM B. KANNEL, MD
1980
BJORN U.G. FOLKOW, MD, PHD
ARTHUR C. GUYTON, MD
1979
KARL H. BEYER, JR, MD
JAMES M. SPRAGUE, PHD
1978
LOUIS TOBIAN, JR, MD
1977
JOHN A. LUETSCHER, MD
JAMES F. TAIT, FRS
SYLVIA A.S. TAIT, BSC, FRS
1976
RAYMOND P. AHLQUIST, PHD
JAMES W. BLACK, MD
1975
LEWIS K. DAHL, MD
JAMES O. DAVIS, MD
WALTER KEMPNER, MD
Past Recipients of the Stouffer Prize
1972
VINCENT P. DOLE, MD
JOHN W. GOFMAN, MD
ROBERT S. GORDON, JR, MD
JOHN L. ONCLEY, MD
1970
IRVINE H. PAGE, MD
SIR GEORGE PICKERING, MD
1969
JEROME W. CONN, MD
JACQUES GENEST, MD
FRANZ GROSS, MD
JOHN H. LARAGH, MD
1968
F. MERLIN BUMPUS, PHD
W. STANLEY PEART, MD
ROBERT SCHWYZER, PHD
LEONARD T. SKEGGS, JR, PHD
1967
JOHN W. CORNFORTH, MD
U.S. VON EULER, MD
PETER HOLTZ, MD
GEORGE J. POPJAK, MD
1966
ERNST KLENK, MD
HARRY GOLDBLATT, MD
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