(Hypertension. 1999;34:466-471.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
Detection and Control of High Blood Pressure in the Community
Do We Need a Wake-Up Call?
From the Departments of Neurology (I.M., D.O.W.) and Health Sciences Research (J.P.W., W.M.O., K.R.B., D.O.W., J.L.C., J.D.S.) and the Division of Hypertension and Internal Medicine (S.G.S., G.L.S.), Mayo Clinic and Mayo Foundation, Rochester, Minn.
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Abstract |
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Abstract—At the community level, the effect of national programs in increasing hypertension awareness, prevention, treatment, and control is unclear. This study evaluated the degree of detection and control of high blood pressure in a random population-based sample of Olmsted County, Minnesota, residents
45 years old, of whom 636 subjects among 1245 eligible
residents agreed to participate. Home interview and home and office
measurements of blood pressure were used to estimate awareness,
treatment, and control rates for hypertension in the community. Mean
blood pressures (±SD) were 138/80±20/12 mm Hg for men and
137/76±23/11 mm Hg for women. The overall prevalence of
hypertension was 53%. The percentage of subjects with treated and
controlled hypertension was 16.6%. Thirty-nine percent of subjects
were unaware of their hypertension. Despite clinical trial evidence of
reduced morbidity and mortality with antihypertensive therapy, recently
reported national data suggest a leveling-off trend for treatment and
control of hypertension. This population-based study supports these
observations and suggests that at a community level, hypertension
awareness and blood pressure control rates are suboptimal, presumably
because of decreased attention to the detection and control of
hypertension.
Key Words: blood pressure • cerebrovascular disorders • hypertension detection and control • stroke
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Introduction |
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Because coronary heart disease and stroke continue to rank as the first and third leading causes of mortality in the United States, with direct and indirect costs up to $260 billion, primary prevention of these disorders is becoming increasingly crucial.1 This goal requires identification and treatment of the associated risk factors in the population.
Hypertension is a main risk factor for both coronary heart disease and stroke. Comparison of the 1976 to 1980 National Health and Nutrition Examination Survey (NHANES II) with the 1988 to 1991 survey (NHANES III, phase I) showed an increase in awareness of high blood pressure from 51% to 73%2 3 and an increase in treatment from 31% to 55%. Control rates (<140/90 mm Hg) increased from 10% to 29% in the same period. However, from the time of the Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V) in 1993,4 awareness, treatment, and control of hypertension may be leveling off or deteriorating. Comparison of the results of the NHANES III, phase I survey showed a decrease in awareness from 73% to 68.4%, treatment from 55% to 53.6%, and control to <140/90 mm Hg from 29% to 27.4%.5
The present study, Stroke Prevention: Assessment of Risk in a
Community (SPARC), was established in 1993 to identify prospectively
the risk factors for stroke and cardiovascular disease
in Olmsted County, Minnesota, a community studied closely for stroke
incidence from the 1950s through the 1990s.6 7 8 9 Randomly
selected subjects were studied with multimodality testing: home and
office blood pressure measurements, transthoracic and
transesophageal echocardiography,
and carotid ultrasonography. This report focuses on estimates of
awareness, treatment, and control rates for hypertension in the
population of Olmsted County, Minnesota, 45 years old to assess
whether recent national survey estimates are applicable at the
community level.
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Methods |
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Population Sampling
The resources of the Rochester Epidemiology Project (REP) were used to enumerate the Olmsted County population.10 With the use of data obtained from medical records at the Mayo Clinic and the Olmsted Medical Center (the major healthcare providers in the county), the REP files index all medical contacts made by residents of the population. Sampling at random from this REP file is equivalent to sampling at random from the population.11 For this study, a stratified sampling scheme was designed with the REP files. The goal was to randomly select 580 persons distributed among 10 strata that were defined by gender and 5 age intervals: 45 to 54 years, 55 to 64 years, 65 to 74 years, 75 to 84 years, and
85 years old.
Study Structure
Data for the SPARC study (which was approved by the Mayo
Institutional Review Board) were collected during a home visit and
clinic testing, which included office blood pressure measurement,
transthoracic echocardiography,
transesophageal echocardiography,
carotid ultrasonography, and medical record review. Data reported
for blood pressure measurement are from home and office visits.
Medical Record Review, Subject Contact, and Informed
Consent
The complete inpatient and outpatient medical record of each
potential study candidate was screened carefully for eligibility by
both the trained coordinator and interviewer, who were registered
nurses experienced in cerebrovascular disorders. Ineligibility criteria
included dementia, severe disability, and terminal illness. Verbal
consent for the home interview was given by telephone within 1 week of
receipt of an explanatory letter that detailed the components of the
study. Written consent for clinic blood pressure testing was obtained
at the home interview.
The medical records for all participants were abstracted by an experienced nurse abstractor who used standardized data collection forms. The records of a randomly selected 20% sample of eligible nonparticipants were also reviewed to determine comparability between the participants and nonparticipants. Data regarding the diagnosis of hypertension and cardiac and cerebrovascular conditions documented up to the time of participation in the SPARC study were collected and used in the analyses of comorbid conditions.
Home Interview
Each home interview was conducted by the nurse coordinator or
the nurse interviewer, both of whom had completed a prerequisite
training program in general interviewing techniques, administration of
the home questionnaire, and measurement of blood pressure with both a
standard mercury column and a random-zero
sphygmomanometer.12 13
The detailed interview documented the presence of medical disorders, including hypertension, diabetes, and cardiovascular disease; previous history of stroke or transient ischemic attacks; medication use; smoking history; alcohol consumption; and recent caffeine intake.
Home Blood Pressure Measurement
During the home visit, a total of 6 blood pressure measurements
were recorded: 2 before (1 standard mercury and 1 random-zero) and
4 after (2 standard mercury and 2 random-zero) the interview. The
subject was seated in a chair with a back support. Smoking was avoided
before and during the measurement. An appropriate-sized cuff was
used, and the blood pressure instrument was positioned on a flat
surface at the approximate level of the heart. Because the Hawksley
random-zero sphygmomanometer causes more arm compression, the standard
mercury readings were obtained first, both before and after the
interview. Initially, both left and right arm pressures were measured;
the higher systolic reading was documented as the first
standard mercury measurement. The arm with the higher pressure was used
for all subsequent measurements. If the systolic readings were
equal bilaterally, the arm with the higher diastolic
pressure was used for all remaining blood pressure measurements. For
all readings, Korotkoff phases 1 and 5 established the levels of
systolic and diastolic pressures, respectively.
Office Blood Pressure Measurement
Each study subject had blood pressure measured by a study
technician in the office setting on 2 consecutive days. After the
patient had rested for 5 minutes in the supine position, parallel sets
of 6 blood pressure readings were obtained with a mercury
sphygmomanometer in the following order: 2 supine, 2 sitting, and 2
standing. One to 2 minutes elapsed between each blood pressure reading
in each position. Another set of parallel blood pressure readings, as
described above, was obtained the next day.
Definitions of Hypertension and Blood Pressure Levels
For age-adjusted prevalence estimates, blood pressure levels
were determined by averaging the last 2 random-zero measurements
obtained at the home visit to allow for comparison of trends between
1986 and 1996. Estimates of awareness, treatment, and control among
hypertensive subjects were obtained as follows: (1) The average of 6
readings (2 home measurements and 4 office measurements made in the
sitting position) was applied to the JNC V criteria for hypertension,
which corresponded closely to the NHANES III, phase I method. (2) The
average of the last 2 random-zero readings obtained at the home visit
was applied to the JNC V. (3) Diagnosis and treatment
information were obtained at the home interview from responses to the
following questions: a. Has a doctor ever told you that you had high
blood pressure or hypertension? b. Are you currently taking any
medications for blood pressure? The responses to these questions were
recorded as "yes," "no," or "do not know." Women who
reported an increase in blood pressure only during pregnancy were not
considered to have hypertension.
Uncontrolled hypertension was defined as either a measured
systolic blood pressure of 140 mm Hg or a
diastolic blood pressure of 90 mm Hg. Controlled
hypertension was defined as a reading <140/90 mm Hg in subjects
with a reported history of hypertension or who took antihypertensive
medications. Aware subjects with hypertension were defined as those who
answered affirmatively to question 3a. Unaware subjects with
hypertension were defined as those answering negatively to question 3a
but whose blood pressure readings met the criteria for hypertension.
Treatment for hypertension was defined as an affirmative answer to
question 3b and confirmation by a review of the subject's
medications.
Statistical Analysis
Prevalences of hypertension and other medical conditions in the
population were estimated14 with their corresponding SEs
by use of SUDAAN15 software to adjust properly for the
different sampling fractions within strata. Multiple linear
regression16 was used to compare blood pressure levels
between 1986 and 1996, and adjustments for differences in comorbidity
and confounding variables were made. The 2-sample
2 test was used to compare percentages of
participants and refusers with various medical
conditions.14 17
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Results |
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Cohort Description
The REP diagnostic indexing system was used to enumerate Olmsted County residents
45 years old. The population was
94% white, 4% Asian or Pacific Islander, 1% black, and 1% from
other races or ethnic groups. During the 2-year period from June 20, 1993, to August 10, 1995, 636 subjects (51%) were recruited from a random sample of 1245 eligible residents and participated in the home interview and blood pressure measurement. Office blood pressure measurements were performed in 598 subjects; 38 dropped out of the study after the home interview.
Of the 230 ineligible subjects, 86 (37%) were excluded because of terminal illness, 70 (30%) because of dementia, 39 (17%) because of functional disability, and 35 (15%) because of esophageal disease that precluded transesophageal echocardiography, which was performed for another part of this study.
A comparison of 15 comorbid conditions, as well as age and gender, between participants and a random sample (20%) of the 609 eligible nonparticipants demonstrated no significant differences, thus confirming that participants were a representative sample of the population (Table).
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Home and Office Blood Pressure
Figure 1 shows age-specific
systolic and diastolic blood pressures in men and
women. Mean blood pressures (±SD) were 138/80±20/12 mm Hg for
men and 137/76±23/11 mm Hg for women. The prevalence of
hypertension by home readings alone was 43±2%. When the 4 office and
2 standard mercury home readings were averaged, the prevalence of
hypertension remained nearly constant at 41±2%. When the subjects'
perception of their hypertension status was included with the observed
readings at home and office, the overall prevalence of hypertension
became 53±2% and 54±2%, respectively. Figure 2 (left) shows the age-specific
prevalences of uncontrolled hypertension. The prevalence of stage 1
hypertension (defined as a reading of 140/90 to 159/99 mm Hg) is
shown in Figure 2 (right).
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Figure 3 shows awareness, treatment, and control among the hypertensive subjects. The percentage of subjects with treated and controlled hypertension was 16.6%. The proportion of subjects who had treated but uncontrolled hypertension was 27.9%. Thirty-nine percent of subjects were unaware of their hypertensive status. These proportions were calculated with the JNC V recommendation of averaging 2 standard mercury blood pressure measurements, which were obtained when the subject was seated at each of the 3 different visits (1 home and 2 office), and they were essentially identical to those obtained with the random-zero measurements at 1 visit alone.
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Discussion |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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This study illustrates a disturbingly low awareness and control of hypertension in a community that is socioeconomically prosperous, with easy access to both primary and tertiary medical care.
The method used in this study to estimate awareness, treatment, and
control rates of hypertension was very similar to that used in NHANES
III, phase I. The national trend toward leveling off of blood pressure
awareness and control that was observed between NHANES III, phase I and
NHANES III, phase II is supported by the data from this community
study. Figure 4 compares the awareness,
treatment, and control of blood pressure between the present study
and NHANES III, phase I, focusing on the cohort of white, non-Hispanic
subjects 50 years old, and suggests decreased awareness and control
in most categories in Olmsted County, Minn. Although no single
community is completely representative of the nation as
a whole, the results are consistent with comparisons of
previous population-based studies of various chronic diseases in
Rochester, Minnesota, and with those of other communities in the United
States. With the exception of a higher proportion of the working
population employed in the healthcare industry (24% versus 8%
nationally) and corresponding higher educational levels, which should
tend to mitigate the observed trends, the demographic characteristics
of Olmsted County residents resemble those of the US white
population.11
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The results of this study were compared with the results from a 1986 Rochester, Minn, survey that used identical blood pressure collection techniques in a randomly selected sample. Compared with the 1986 survey, the mean systolic blood pressure is 6.6 mm Hg higher and the mean diastolic blood pressure is 3.6 mm Hg higher in the present study. These differences represent a 4.9% higher systolic blood pressure and a 5.0% higher diastolic blood pressure. In the present study, fewer subjects were aware that they had high blood pressure, and fewer subjects had their blood pressure controlled with treatment than in 1986. These differences are consistent for both genders, all ages, and all blood pressures. Systolic and diastolic pressures are significantly higher in the present study than in 1986, even after adjustment for differences in comorbidity and confounding variables, including age, sex, body mass index, cigarette smoking, ischemic heart disease, congestive heart failure, and aortic regurgitation (P=0.001). Evidence demonstrates that population demographics in Olmsted County, Minnesota, have not changed significantly during the past decade.18
These disconcerting findings of increasing hypertension and decreasing awareness and control of hypertension are supported by data from the Minnesota Heart Survey, which reported a decline in the proportion of hypertensive men who were aware of their hypertension, treated, and controlled, from 66% (1980 to 1982) to 61% (1990 to 1992) and a similar decline in women from 77% (1985 to 1989) to 73% (1990 to 1992).19
An Iowa population-based cohort reported an increase in the prevalence
of increased systolic pressure during the 1980s.20
In contrast, data regarding community blood pressure levels on the East
Coast revealed an overall decrease in the prevalence of
systolic hypertension.20 Both studies defined
hypertension by the criteria of the World Health Organization
(160/95 mm Hg).20 Substitution of the JNC V
criteria for hypertension (140/90 mm Hg) would attenuate these
reported differences. The reasons for the apparent geographic
differences are unclear; changing demographics and baseline health may
have had an impact on the degree of detection and the aggressiveness of
treatment.
A retrospective blood pressure study that involved a Portland, Ore–based cohort >65 years of age revealed that although the proportion of subjects with treated hypertension increased dramatically during the 1980s, the proportion of subjects with persistent uncontrolled hypertension at the beginning of the 1990s approached 70%.21
Data conflict in regard to the accuracy and reliability of the random-zero Hawksley sphygmomanometer.22 23 In this study, comparison of standard mercury and random-zero measurements showed a negligible methodological difference of 0.8±7.0 mm Hg systolic and 0.5±4.9 mm Hg diastolic. The use of the average of the 2 after-interview random-zero measurements as the summary home measurements provided comparability with the 1986 survey and eliminated the selection effect of use of the arm with the initially higher standard reading and the before-interview potential blood pressure increase. This was done specifically to address the issue of "regression to the mean" that could lead to initial spurious high blood pressure readings. These data suggest that if used properly, random-zero measurements are accurate and comparable to values obtained with standard column sphygmomanometry, but they do not provide an advantage.
This study demonstrates that at the community level, rates of awareness and control of hypertension are suboptimal. The results of this survey confirm recent national data that demonstrate a decline in awareness, treatment, and control rates for hypertension. The explanation for this decline is not readily apparent from our study but is an important subject for future clinical research. Understanding the causes is a necessary first step toward reversing these unfavorable trends. Several potential questions could be explored. What is the contribution of complacency by healthcare providers and the public? Has there been a reduction at the community level in programs for blood pressure awareness and control in favor of other health issues? What is the impact of the high cost of contemporary therapies on control and long-term compliance with therapy? Have healthcare providers accepted the need to treat isolated systolic hypertension in the elderly? What is the effect of managed care? These questions and others need to be answered if progress is to be made in the prevention of stroke and cardiovascular disease. With the overall increasingly prolonged survival of the elderly population, continued efforts are necessary to clarify the definition of hypertension, identify prognostic indicators for target organ damage, and heighten community awareness of the risks of increased blood pressure across the spectrum of severity.
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Acknowledgments |
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This study was supported in part by grants NS-06663 and AR-30582 from the National Institutes of Health, Public Health Service. We are indebted to Lori A. Reese for her enthusiastic assistance with patient recruitment; Elizabeth E. Worrall, Tanya M. Petterson, and Teresa J.H. Christianson for their assistance with analysis; Connie Bissen for excellent technical assistance; and Deborah M. Pluth for her efforts in typing the manuscript.
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Footnotes |
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Reprint requests to Irene Meissner, MD, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Received February 17, 1999; first decision March 11, 1999; accepted May 11, 1999.
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P. A. Ades, T. E. Kottke, N. Houston Miller, J. C. McGrath, N. B. Record, and S. S. Record Task Force #3--getting results: who, where, and how? J. Am. Coll. Cardiol., August 21, 2002; 40(4): 615 - 630. [Full Text] [PDF]
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J. P. Hellermann, G. S. Reeder, S. J. Jacobsen, S. A. Weston, J. M. Killian, and V. L. Roger Longitudinal Trends in the Severity of Acute Myocardial Infarction: A Population Study in Olmsted County, Minnesota Am. J. Epidemiol., August 1, 2002; 156(3): 246 - 253. [Abstract] [Full Text] [PDF]
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S. J. Taler, S. C. Textor, and J. E. Augustine Resistant Hypertension: Comparing Hemodynamic Management to Specialist Care Hypertension, May 1, 2002; 39(5): 982 - 988. [Abstract] [Full Text] [PDF]
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R. S. Vasan, A. Beiser, S. Seshadri, M. G. Larson, W. B. Kannel, R. B. D'Agostino, and D. Levy Residual Lifetime Risk for Developing Hypertension in Middle-aged Women and Men: The Framingham Heart Study JAMA, February 27, 2002; 287(8): 1003 - 1010. [Abstract] [Full Text] [PDF]
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K. M. Detre and R. Holubkov Coronary Revascularization on Balance: Robert L. Frye Lecture Mayo Clin. Proc., January 1, 2002; 77(1): 72 - 82. [Abstract] [PDF]
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S. Seshadri, P. A. Wolf, A. Beiser, R. S. Vasan, P. W. F. Wilson, C. S. Kase, M. Kelly-Hayes, W. B. Kannel, and R. B. D'Agostino Elevated Midlife Blood Pressure Increases Stroke Risk in Elderly Persons: The Framingham Study Arch Intern Med, October 22, 2001; 161(19): 2343 - 2350. [Abstract] [Full Text] [PDF]
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 D. J. Hyman and V. N. Pavlik Characteristics of Patients with Uncontrolled Hypertension in the United States N. Engl. J. Med., August 16, 2001; 345(7): 479 - 486. [Abstract] [Full Text] [PDF]
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S. T. Turner, G. L. Schwartz, A. B. Chapman, and E. Boerwinkle C825T Polymorphism of the G Protein {beta}3-Subunit and Antihypertensive Response to a Thiazide Diuretic Hypertension, February 1, 2001; 37(2): 739 - 743. [Abstract] [Full Text] [PDF]
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H. R. Black, W. J. Elliott, J. D. Neaton, G. Grandits, P. Grambsch, R. H. Grimm Jr, L. Hansson, Y. Lacouciere, J. Muller, P. Sleight, et al. Baseline Characteristics and Early Blood Pressure Control in the CONVINCE Trial Hypertension, January 1, 2001; 37(1): 12 - 18. [Abstract] [Full Text] [PDF]
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Y. Agmon, B. K. Khandheria, I. Meissner, G. L. Schwartz, T. M. Petterson, W. M. O'Fallon, F. Gentile, J. P. Whisnant, D. O. Wiebers, and J. B. Seward Independent Association of High Blood Pressure and Aortic Atherosclerosis : A Population-Based Study Circulation, October 24, 2000; 102(17): 2087 - 2093. [Abstract] [Full Text] [PDF]
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D. M. Lloyd-Jones, J. C. Evans, M. G. Larson, C. J. O'Donnell, E. J. Roccella, and D. Levy Differential Control of Systolic and Diastolic Blood Pressure : Factors Associated With Lack of Blood Pressure Control in the Community Hypertension, October 1, 2000; 36(4): 594 - 599. [Abstract] [Full Text] [PDF]
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J. D. Swales Hypertension in the Political Arena Hypertension, June 1, 2000; 35(6): 1179 - 1182. [Full Text] [PDF]
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 C. Willis, B. Gaffney, and J. Yarnell Hypertension: what do people think? A survey in Northern Ireland of public knowledge and attitudes concerning high blood pressure Health Education Journal, January 1, 2000; 59(4): 308 - 314. [Abstract] [PDF]
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