(Hypertension. 1999;34:808-812.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
From the Hypertension Unit, Hospital Italiano de Buenos Aires, Argentina.
Correspondence to José Alfie, MD, Unidad de Hipertensión Arterial, Servicio de Clínica Médica, Hospital Italiano, Gascón 450 (1181), Buenos Aires, Argentina. E-mail alfie{at}connmed.com.ar
| Abstract |
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60 years) patients. Pulse
pressure decreased in parallel with stroke index from age >30 to 40 to
49 years. Upright posture, however, eliminated this difference through
a larger orthostatic fall in stroke index and pulse
pressure in the youngest patients. After age 50 years, pulse pressure
exhibited a progressive widening despite the further age-related
decrease in stroke index. Supine, upright, and 24-hour pulse pressure
fitted a curvilinear correlation with age (r=0.55, 0.56,
and 0.68, respectively, P<0.001), with a transition at
age 50 years. Before age 50 years, 24-hour pulse pressure correlated
positively with stroke volume (r=0.5,
P<0.001) and negatively with arterial
compliance (SV/PP ratio, r=-0.37,
P<0.01). In contrast, in men
50 years old, 24-hour
pulse pressure correlated negatively with the SV/PP ratio
(r=-0.5; P<0.01), without significant
influence of stroke volume. Thus, in hypertensive men, the age-related
change in stroke volume significantly accounted for the change in
clinic and ambulatory pulse pressure during young adulthood, but its
contribution decreased after the fifth decade.
Key Words: : age pulse pressure stroke volume hypertension, arterial blood pressure monitoring
| Introduction |
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High cardiac output characterizes the early phase of arterial hypertension. As patients get older, however, cardiac output gradually decreases at the expense of stroke volume.5 The age-related decrease in stroke volume, by reducing pulse pressure, could explain the low proportion of systolic hypertension among middle-aged hypertensive individuals.6 A reduction in arterial compliance after the middle adult years, however, could overcome the negative effect of the decreasing stroke volume on pulse pressure in older patients.
In addition to ventricular ejection and structural characteristics of the arterial wall, the amplitude of pulse pressure is passively related to the level of mean arterial pressure (MAP).7 Therefore, unless MAP is controlled at the same level, it would not be possible to analyze the effect of age on pulse pressure.7 Accordingly, in the present study we investigated the effect of age on conventional and ambulatory pulse pressure and its underlying mechanisms in unmedicated hypertensive men with the same level of MAP. Increasing age is associated with a greater increase in clinic than ambulatory blood pressure.8 9 10 Therefore, in this study patients were matched by the level of ambulatory MAP.
| Methods |
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140 mm Hg systolic or
90 mm Hg
diastolic, or both, on 2 occasions) with body mass index
(BMI)
35 kg/m2 who had no evidence of secondary
cause of hypertension or major diseases and were free of
antihypertensive medication for
2 weeks (1 month in the case of
diuretics). Patients were carefully matched according to
daytime MAP. Finally, 77 patients with daytime MAP between 95 and
114 mm Hg were selected. Anthropometric measurements (height and weight) were made after patients had removed their shoes and upper garments. BMI was calculated as weight (in kilograms) divided by height (in meters squared).
Ambulatory blood pressure was recorded in the nondominant arm every
10 minutes between 7 AM and 11 PM and every 20
minutes between 11 PM and 7 AM with a Spacelabs
90207 monitor. Nighttime was defined according to the period of
nighttime sleep based on the patient's diary. Readings of
systolic blood pressure (SBP) >260 or <70 mm Hg,
diastolic blood pressure (DBP) >150 or <40 mm Hg,
and pulse pressure >150 or <20 mm Hg were automatically
discarded. Only studies with
90% of valid readings were included.
Patients were instructed to avoid smoking and avoid drinking tea or coffee the morning of the hemodynamic study. Hemodynamic evaluations were performed immediately before or after the 24-hour ambulatory blood pressure monitoring in most cases, or at least within the same week. Blood pressure was determined with a mercury sphygmomanometer on the right arm with cuffs of adequate size. Stroke volume was estimated noninvasively by impedance cardiography (Minnesota model 304B, Surcom Inc) by use of a technique and formula described elsewhere.11 12 Blood pressure and tracings of the first derivative of thoracic impedance were obtained in duplicate after 10 minutes of supine rest and during the first 3 minutes of upright position by observers blinded to the ambulatory blood pressure findings. Heart rate and stroke volume were calculated from tracings of consecutive cardiac cycles recorded at a paper speed of 50 mm/s. Several reports have shown the accuracy of impedance cardiography for estimating stroke volume and cardiac output.13 14 In our hands, the correlation coefficient between simultaneous impedance cardiography and thermodilution determinations of cardiac output was 0.94, and the mean paired difference was 0.08 L/min (95% CI, -0.12 to 0.27 L/min).12 The regression equation for the 2 methods was y=-0.76+1.17x, where y=cardiac output by impedance cardiography and x=cardiac output by thermodilution.12 Stroke index was obtained by dividing stroke volume by meters squared. Pulse pressure was calculated as the difference between SBP and DBP (using the Korotkoff phase V for defining DBP). The ratio of stroke volume to brachial pulse pressure (SV/PP) was used as a crude measure of systemic arterial compliance.15
Statistical Analysis
Results are expressed as mean±SD. Subjects were grouped into 5
age strata (<30, 30 to 39, 40 to 49, 50 to 59, and
60 years).
Differences among age groups were assessed by ANOVA with Bonferroni's
t test when the ANOVA was significant. The relationships of
pulse pressure and age were also evaluated by use of linear and
quadratic models. The transition in the curve of pulse pressure and age
was estimated by multiple regression analysis including a dummy
variable. Within-group differences were evaluated by paired
t test. Associations between 24-hour pulse pressure and
hemodynamic variables were assessed by simple
correlation coefficients.
| Results |
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Supine Pulse Pressure
As shown in Figure 1, supine stroke
index decreased significantly (P<0.05 by ANOVA) between the
first (<30 years) and the fifth (
60 years) age groups, with a
parallel narrowing of pulse pressure up to age 40 to 49 years
(P<0.05 by ANOVA). After age 50 years, pulse pressure
showed a progressive widening despite the further decrease in stroke
index (Figure 1). In contrast to stroke index, there were no
significant age-related differences in heart rate. The SV/PP ratio
remained constant up to the third age group, reflecting the parallel
change of stroke index and pulse pressure during young adulthood. It
fell significantly, however, after age 50 years, indicating the
progressive dissociation between pulse pressure and stroke index in the
older decades (Figure 2).
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Upright Pulse Pressure
When patients assumed an upright position (Figure 1),
stroke index and pulse pressure showed a parallel fall, but the changes
were significantly attenuated by age (1-way ANOVA, P<0.05
and <0.001, respectively). Therefore, in the upright position, pulse
pressure became "normal" in the youngest group but remained
significantly increased in the oldest group (Figure 1). The
SV/PP ratio decreased in the vertical position (P<0.001),
indicating a greater postural fall in stroke index than the
corresponding change in pulse pressure (Figure 1).
Ambulatory Pulse Pressure
Supine, upright, and 24-hour pulse pressure fitted a curvilinear
correlation with age (r=0.58, 0.56, and 0.80, respectively,
P<0.001), with a transition at age 50 years for the 3
correlations. Supine pulse pressure overestimated (8±10 mm Hg,
P<0.001) and upright pulse pressure underestimated
(-4±11 mm Hg, P<0.003) the corresponding 24-hour
measurement. Interindividual variation was much greater for supine and
upright pulse pressure than for 24-hour pulse pressure (Figure 2).
The paired difference between daytime and nighttime pulse pressure reached statistical significance but showed a considerable overlap (50±8 versus 48±7 mm Hg, respectively, P<0.01). As shown in Figure 3, MAP exhibited a much larger decrease from day to night (105±5 versus 87±8 mm Hg, P<0.001), with a progressive attenuation in the older decades. The night-day ratio of pulse pressure showed a better correlation with the night-day ratio for SBP (r=0.59, P<0.001) than with the corresponding night-day ratio for MAP, DBP, or heart rate (r=0.37, P<0.002; r=0.23, P<0.05; and r=0.23, P<0.05, respectively).
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The hemodynamic correlates for ambulatory pulse
pressure were assessed separately in the <50- and
50-year-old groups
(n=51 and 26, respectively). In younger men, 24-hour pulse pressure
showed positive and significant correlations with both supine and
upright stroke volume (r=0.47, P<0.002 and
r=0.44, P<0.002, respectively) and a negative
correlation with supine SV/PP ratio (r=-0.37,
P<0.01). In contrast, in men
50 years old, 24-hour pulse
pressure showed negative and significant correlations with both supine
and upright SV/PP ratio (r=-0.5, P<0.01 and
r=-0.6, P<0.002, respectively), without
significant correlation with stroke volume (Figure 4).
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| Discussion |
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The postural decrease in pulse pressure was smaller than the corresponding change in stroke volume. The orthostatic decrease in the SV/PP ratio suggests an adaptive response of conduit arteries to attenuate the effect of the postural decrease in blood flow on pulse pressure.
Widening of pulse pressure after age 50 years was independent of the level of stroke volume. Moreover, a progressive dissociation between pulse pressure and stroke volume was noted after that age. The reduction in arterial compliance (indicated by the progressive decrease in the SV/PP ratio) overcame the effect of the decreasing stroke volume on pulse pressure, explaining the lack of correlation between stroke volume and pulse pressure after age 50 years.
Narrowing of pulse pressure during young adulthood could favor the
change from a systolic to a diastolic pattern of
hypertension in middle-aged patients. The reciprocal change in the
proportion of systolic and diastolic forms of
hypertension between 25 and 65 years observed in population
studies6 16 resembles the curvilinear change in pulse
pressure reported here. In a national survey from
Argentina,16 systolic hypertension (SBP
140 and
DBP <90 mm Hg) was found in
42% of the hypertensive
population before age 25 years and fell to <20% between age 35 and 54
years, returning to the initial proportion after age 65 years. A
transient narrowing of pulse pressure produced by the age-related
decrease in stroke volume could favor these changes in the pattern of
blood pressure elevation. A decrease in arterial compliance
after the middle adult years could overcome the effect of the
decreasing stroke volume.
The age-related change in SV/PP ratio in our study resembles the findings reported by de Simone and colleagues17 in normotensive individuals. In agreement with their results, SV/PP ratio remained relatively constant between 17 and 50 years, after which it decreased steeply.
In the present study, brachial instead of aortic pulse pressure was used for the calculation of the SV/PP ratio. An increase in pulse-wave velocity with aging causes a proximal summation of the forward and backward waves, attenuating the difference between central and peripheral pulse pressure.3 Therefore, the use of brachial instead of aortic pulse pressure could underestimate arterial compliance in young patients.
Previous studies have found better correlations between pulse pressure and target organ damage18 and cardiovascular risk in hypertension19 when ambulatory rather than conventional measurements were used. The present data show that postural differences in pulse pressure represent a source of discrepancy between conventional and ambulatory measurements. Supine pulse pressure overestimated, and upright pulse pressure underestimated, the corresponding ambulatory readings. The pulse pressure value in the upright position would be expected to be similar to that during daytime (when patients spend most of the time in the vertical position). Sitting or walking pulse pressure, however, could attenuate the mere effect of upright posture on daytime pulse pressure value.
It has been well established that increasing age attenuates the nocturnal fall in SBP and DBP and heart rate20 ; however, the corresponding change in pulse pressure has been less explored. The present study shows that in contrast to the diurnal change in MAP, there was a considerable overlap between daytime and nighttime pulse pressure through the adult age range. Correlation analyses indicate that the magnitude of the nocturnal fall in pulse pressure is more closely related to the nocturnal change in SBP than to the change in DBP. Hemodynamic changes evoked during sleep could explain the smaller nocturnal decrease in pulse pressure compared with the MAP. The increase in venous return and stroke volume during recumbency or the nocturnal bradycardia could maintain a wide pulse pressure despite the passive improvement of arterial compliance due to a lower MAP.
Calculation of daytime and nighttime pulse pressure from SBP and DBP
reported in larger studies shows comparable findings. For example, in
1052 hypertensive men from the PIUMA study,10 daytime and
nighttime pulse pressure averaged 53 and 53 mm Hg, 49 and 46
mm Hg, 48 and 44 mm Hg, 50 and 48 mm Hg, 57 and 56
mm Hg, and 61 and 61 mm Hg from the third to the eighth decade,
respectively. Similarly, in 517 normotensive men from the Belgian
Population Study,8 daytime and nighttime pulse pressure
averaged 50 and 49 mm Hg between 20 and 39 years, 46 and 44
mm Hg between 40 and 59 years, and 52 and 49 mm Hg in those
60
years old.
In conclusion, the study shows a curvilinear change of pulse pressure with age in men with similar levels of MAP. Before the age of 50 years, the amplitude of pulse pressure was proportional to the changes in stroke volume. In contrast, a progressive dissociation between stroke volume and pulse pressure was noted after age 50 years, indicating a reduction in arterial compliance. Ambulatory pulse pressure reproduced the U-shaped relation with age observed with supine measurements, with a considerable overlap between daytime and nighttime readings.
Received May 10, 1999; first decision June 4, 1999; accepted July 19, 1999.
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