doi: 10.1161/hy1001.095926
(Hypertension. 2001;38:962.)
© 2001 American Heart Association, Inc.
Hypertension Electronic Pages |
Hypertension Online Only
October 2001
The Scientific Publishing Committee has approved Hypertension to receive a limited number of electronic pages. These electronic pages will be used to help increase the number of referenceable pages for the journal by allowing us to publish Editorials, Letters to the Editors and their respective responses, Scientific Contributions, and other materials online. Thus, Hypertension Online material will be indexed in Index Medicus, MEDLINE, and PubMed. Each online item will also be featured in the Table of Contents on the cover, denoted by a green star, as well as in the Table of Contents within the journal, denoted by the letter e in front of the page number. Hypertension is available online at http://www.hypertensionaha.org
Progress in Hypertension Research
1900–2000
Jacques Genest
Abstract—
The author reviews the various factors (sodium, aldosterone, renin-angiotensin system, and norepinephrine; each of these factors being influenced by others) involved in the mechanism of human hypertension. A coherent picture is presented, with the final pathway of these mechanisms converging on the renin-angiotensin system in the presence of a positive sodium balance and responsible for arteriolar resistance and responsiveness to pressor agents. This would correspond to the labile phase of hypertension, which leads with time to arteriolar restructuring and the increased media/lumen ratio, as demonstrated by Schiffrin and coworkers, and which can revert to normal structure with the administration of antihypertensive drugs such as converting-enzyme inhibitors, calcium-blocking drugs, and antagonists of the angiotensin II type 1 receptor. The author also presents the experience obtained in the Hypertension Clinic of the Clinical Research Institute of Montréal, which has been in existence since 1953; this experience is based on the observation of senior observers (clinical scientists, clinicians, and nurses) that the blood pressure of hypertensive patients can be controlled to normal levels in almost all cases for years and decades with a proper combination of the present antihypertensive drugs. (Hypertension. 2001;38:e13–e18.)
Letters to the Editor
(Hypertension. 2001;38:e19-e25.)
Correction
(Hypertension. 2001;38:e26.)
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