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(Hypertension. 2008;51:e12.)
© 2008 American Heart Association, Inc.

Letters to the Editor

Response to Resistin, Glomerular Filtration Rate, and Insulin Resistance

Mayo Clinic, Rochester, Minn

Yasuharu et al¹ found an inverse association between plasma resistin and estimated glomerular filtration rate in a community-based cohort of Japanese individuals, findings that are consistent with our report.² Furthermore, they observed plasma resistin to be a significant determinant of the homeostasis model assessment of insulin resistance, independent of estimated glomerular filtration rate. We also noted plasma resistin to be correlated with the homeostasis model assessment of insulin resistance after adjustment for age in blacks (=0.11; P=0.002), as well as in whites (=0.09; P=0.027). However, after adjustment for age, sex, estimated glomerular filtration rate, and body mass index, plasma resistin was not significantly associated with the homeostasis model assessment of insulin resistance in either ethnic group (β±SE=0.05±0.06, P=0.44 in blacks and β±SE=–0.08±0.05, P=0.096 in whites). Although some previous studies^3,4 have reported an association between resistin and insulin resistance, others⁵ have not been able to demonstrate any such association. Therefore, the finding by Yasuharu et al¹ that, in subjects without chronic kidney diseases, plasma resistin reflects insulin resistance status independent of renal function needs further confirmation.

	Acknowledgments

 
Sources of Funding

This work was supported by grants HL-81331 and M01 RR00585 from the National Institutes of Health.

Disclosures

None.

	References

Top References

 
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3. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003; 149: 331–335.[Abstract]

4. Ohmori R, Momiyama Y, Kato R, Taniguchi H, Ogura M, Ayaori M, Nakamura H, Ohsuzu F. Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease. J Am Coll Cardiol. 2005; 46: 379–380.[Free Full Text]

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This Article Extract Full Text (PDF) All Versions of this Article: 51/2/e12    most recent HYPERTENSIONAHA.107.102053v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ellington, A. A. Articles by Kullo, I. J. Search for Related Content PubMed Articles by Ellington, A. A. Articles by Kullo, I. J. Related Collections Risk Factors