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Figure 4. MR-1 overexpression facilitates proinflammatory response induced by Ang II. AC, Quantitative showing the number of 7/4-, Mac-1-, and Macpositive cells in the hearts of WT and TG mice (n=4). D, Myocardial MPO activity in cardiac tissue samples from TG and WT mice (n=6). MPO activity is expressed as units per 100 mg of wet tissue weight. E, Western blot analysis of TNF- , IL-6, and MCP-1 protein expression in myocardium obtained from TG and WT mice (n=6). Top, representative blots; bottom, quantitative results. Values are mean±SEM. *P<0.01 for difference from WT sham values. P<0.01 for difference from WT Ang II values. F, Effects of MR-1 on Ang IIinduced TNF- , MCP-1, and IL-6 promoter activities in cardiac myocytes.
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