Published Online
on June 24, 2002

A more recent version of this article appeared on August 1, 2002

This Article Full Text (PDF) All Versions of this Article: 40/2/186    most recent 01.HYP.0000024349.85680.87v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Price, D. A. Articles by Hollenberg, N. K. Search for Related Content PubMed Articles by Price, D. A. Articles by Hollenberg, N. K. Related Collections Clinical Studies

Submitted on February 18, 2002
Revised on March 12, 2002

Renal Perfusion in Blacks

Deborah A. Price^*; Naomi D.L. Fisher; M. Cecilia Lansang; Radomir Stevanovic; Gordon H. Williams; and Norman K. Hollenberg

From the Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

^* To whom correspondence should be addressed. E-mail: daprice{at}partners.org.

Abstract—We have reported that an increased intrarenal renin-angiotensin system activity may be responsible for the reduction in renal plasma flow (RPF) in apparently healthy blacks in comparison to healthy whites during high salt balance. To ascertain whether these differences only exist in the high salt state, we performed the following study, concentrating on the manipulation of the renin system during low salt intake. We measured in 19 healthy blacks and 22 healthy whites para-aminohippurate and inulin clearances as an indication of RPF and glomerular filtration rate, respectively, on both high (200 mmol/d) and low (10 mmol/d) salt balance in random order. A subset of 11 blacks and 12 whites additionally received an angiotensin II infusion while in low salt balance (3 ng/kg per minute for 45 minutes) and captopril to assess differences in RPF response to a converting enzyme inhibitor. The 19 whites had significantly higher RPF when compared with blacks (P=0.033) when studied on high salt. However, during low salt balance, the RPFs were comparable in the 2 groups. Plasma renin activity was similar in the 2 groups on both diets. In the subset that received angiotensin II and captopril while in low salt balance, the renal vascular response was not different in whites and blacks. These data provide additional support for the concept that the intrarenal tissue renin system is more active in blacks than whites on a typical (high salt) diet and that the difference reflects primarily incomplete tissue renin suppression with an increase in salt intake. The mechanism involved may contribute to the increased susceptibility to renal injury in blacks.

Key words: sodium • blacks • kidney • renal circulation • renin-angiotensin system

This article has been cited by other articles:

				M. Azizi, J. Menard, A. Bissery, T.-T. Guyene, and A. Bura-Riviere Hormonal and Hemodynamic Effects of Aliskiren and Valsartan and Their Combination in Sodium-Replete Normotensive Individuals Clin. J. Am. Soc. Nephrol., September 1, 2007; 2(5): 947 - 955. [Abstract] [Full Text] [PDF]

				R. Liu, J. L. Garvin, Y. Ren, P. J. Pagano, and O. A. Carretero Depolarization of the macula densa induces superoxide production via NAD(P)H oxidase Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1867 - F1872. [Abstract] [Full Text] [PDF]

				B. J. H. van den Born, U. P.F. Honnebier, R. P. Koopmans, and G. A. van Montfrans Microangiopathic Hemolysis and Renal Failure in Malignant Hypertension Hypertension, February 1, 2005; 45(2): 246 - 251. [Abstract] [Full Text] [PDF]

				M. H. Weinberger More on the Sodium Saga Hypertension, November 1, 2004; 44(5): 609 - 611. [Full Text] [PDF]

				V. M. Vehaskari, T. Stewart, D. Lafont, C. Soyez, D. Seth, and J. Manning Kidney angiotensin and angiotensin receptor expression in prenatally programmed hypertension Am J Physiol Renal Physiol, August 1, 2004; 287(2): F262 - F267. [Abstract] [Full Text] [PDF]

				D. W. Jones Dietary Sodium and Blood Pressure Hypertension, May 1, 2004; 43(5): 932 - 935. [Full Text] [PDF]

				A. Aviv, N. K. Hollenberg, and A. Weder Urinary Potassium Excretion and Sodium Sensitivity in Blacks Hypertension, April 1, 2004; 43(4): 707 - 713. [Abstract] [Full Text] [PDF]

				B. J. Materson High Blood Pressure in African Americans Arch Intern Med, March 10, 2003; 163(5): 521 - 522. [Full Text] [PDF]

				H. Kobori, A. Nishiyama, Y. Abe, and L. G. Navar Enhancement of Intrarenal Angiotensinogen in Dahl Salt-Sensitive Rats on High Salt Diet Hypertension, March 1, 2003; 41(3): 592 - 597. [Abstract] [Full Text] [PDF]