Published Online
on September 23, 2002

A more recent version of this article appeared on October 1, 2002

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Submitted on June 7, 2002
Revised on July 3, 2002

Goal-Oriented Hypertension Management. Translating Clinical Trials to Practice

Gregory M. Singer; Munavvar Izhar; and Henry R. Black^*

From the Rush University Hypertension Service, Rush-Presbyterian St. Luke's Medical Center, Chicago, Ill.

^* To whom correspondence should be addressed. E-mail: hblack{at}rush.edu.

Abstract—Several clinical trials using a blood pressure (BP) treatment algorithm focused on a predetermined goal have achieved better control rates than those of national survey data. These trials reached the Sixth Joint National Committee on the Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC VI) diastolic blood pressure (DBP) goal of <90 mm Hg in >90% of volunteers and systolic blood pressure (SBP) goal of <140 mm Hg in >60% of volunteers. We evaluated BP control of 437 consecutive patients after at least one year of follow up in a specialist clinic which employed "goal-oriented management," ie, treating to a specific BP goal without a formal drug treatment algorithm, to determine whether JNC VI goals could be achieved. Overall, 276 (63%) patients achieved SBP goal, with 376 (86%) at DBP goal and 358 (59%) at both goals. Only 23% of patients were on monotherapy, with 34% requiring 2 drugs and 37% requiring 3 or more medications. There was no substantial difference in BP control rates among age, gender, and ethnicity subgroups. However, in the 20% of patients who were diabetic, only 52% had a BP of <140 mm Hg and <90 mm Hg, whereas fewer (22% and 15%, respectively) achieved the more stringent goals of JNC VI and the American Diabetic Association (ADA)/National Kidney Foundation (NKF). Goal-oriented management achieved dramatically better control rates than what is reported. Although DBP control was easy to achieve, achieving SBP goal still remained difficult. Employing goal-oriented management can translate BP control results achieved in clinical trials into outpatient practice.

Key words: hypertension, detection and control • blood pressure monitoring • antihypertensive therapy • antihypertensive agents

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