Published Online
on December 23, 2002

A more recent version of this article appeared on March 1, 2003

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Submitted on October 7, 2002
Revised on October 30, 2002

Erythrocyte Sodium-Lithium Countertransport and Blood Pressure. A Genome-Wide Linkage Study

Alan B. Weder^*; Maria Carolina Delgado; Xiaofeng Zhu; Lillian Gleiberman; Donghui Kan; and Aravinda Chakravarti

From the Division of Hypertension, University of Michigan (A.B.W., M.C.D., L.G.), Ann Arbor; the Department of Preventive Medicine and Epidemiology, Loyola University Medical Center (X.Z., D.K.), New Orleans, La; and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine (A.C.), Baltimore, Md.

^* To whom correspondence should be addressed. E-mail: aweder{at}umich.edu.

Abstract—Increased activity of erythrocyte sodium-lithium countertransport is associated with essential hypertension. Sodium-lithium countertransport is highly heritable, but no single gene product mediating the exchange or explaining the association of increased sodium-lithium countertransport activity and hypertension has been identified. We performed a linkage study by using erythrocyte sodium-lithium countertransport as a quantitative phenotype and genome-wide markers at an average resolution of 10 cM to identify quantitative trait loci explaining sodium-lithium countertransport activity. A peak LOD score of 2.83 was detected on chromosome 15q at D15S642, a marker previously shown to be linked to blood pressure. Several genes mapped to this region are possible candidates for factors affecting erythrocyte sodium-lithium countertransport and/or blood pressure. Further studies confirming the presence of a quantitative trait locus in this region and evaluating these candidate genes may help explain the association of elevated sodium-lithium countertransport and hypertension.

Key words: hypertension, essential • erythrocytes • membranes • genes • genetics

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