Published Online
on December 2, 2002

A more recent version of this article appeared on January 1, 2003

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Submitted on September 6, 2002
Revised on September 20, 2002

Gene Expression Profiling in Hypertension Research. A Critical Perspective

Michal Pravenec; Caroline Wallace; Timothy J. Aitman; and Theodore W. Kurtz^*

From the Institute of Physiology, Czech Academy of Sciences and The Center for Integrated Genomics (M.P.), Prague, Czech Republic; Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College (C.W., T.J.A.), London, UK; and Department of Laboratory Medicine, University of California (T.W.K.), San Francisco, California.

^* To whom correspondence should be addressed. E-mail: KurtzT{at}Labmed2.ucsf.edu.

Abstract—Recent advances in molecular biology and technology have made it possible to monitor the expression levels of virtually all genes simultaneously. As the tools for gene expression profiling have become more widely available, the number of investigators applying this technology in hypertension research, as in other fields of biomedical research, has grown rapidly. At the same time, numerous articles have been published that discuss the technical aspects of gene profiling and its promise for advancing research on the pathogenesis and treatment of multiple clinical disorders. However, much of the research carried out with gene expression profiling has been of a correlational or descriptive nature, and the true value of this technology is unclear. Despite the initial wave of enthusiasm for gene expression profiling, its actual utility for studying multifactorial disorders like hypertension remains to be established. In this review, we offer a critical perspective on the use of gene expression profiling in hypertension research and discuss some emerging strategies for taking this technology beyond the limits of correlational and descriptive studies.

Key words: gene expression • hypertension, essential • gene expression • genes • DNA

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