Published Online
on January 27, 2003

A more recent version of this article appeared on February 1, 2003

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Submitted on October 1, 2002
Revised on October 18, 2002

Lipid Peroxidation Is Not Increased in Patients With Untreated Mild-to-Moderate Hypertension

Jean-Luc Cracowski^*; Jean-Philippe Baguet; Olivier Ormezzano; Janine Bessard; Françoise Stanke-Labesque; Germain Bessard; and Jean-Michel Mallion

From the Pharmacology and Cardiology Departments, Grenoble University Hospital, Grenoble, France.

^* To whom correspondence should be addressed. E-mail: Jean-Luc.Cracowski{at}ujf-grenoble.fr.

Abstract--In contrast with the huge amount of experimental data available, only few and somewhat unconvincing clinical studies support the hypothesis that oxidative stress is involved in the early stages of essential hypertension in humans. Isoprostanes are chemically stable lipid peroxidation products of arachidonic acid, the quantification of which provides a novel approach to the assessment of oxidative stress in vivo. The main objective of this study was to quantify the urinary levels of 15-F_2t-IsoP in the early stages of essential hypertension, using gas chromatography/mass spectrometry, by comparing 30 patients with never-treated mild-to-moderate hypertension with 30 gender- and age-paired healthy controls. Urinary 15-F_2t-IsoP levels were not significantly different in hypertensive patients (69±36 pmol/mmol creatinine) compared with controls (75±34 pmol/mmol creatinine, 95% confidence intervals on differences: -23 to 13). No significant correlation was found between basal urinary 15-F_2t-IsoP levels and age, low-density lipoprotein cholesterol, glucose, clinical pulse pressure, carotid intima-media thickness, left ventricular mass index, or aortic pulse wave velocity. In conclusion, this study shows that lipid peroxidation is not increased in never-treated mild-to-moderate hypertension. This suggests that oxidative stress is not implicated in the pathogenesis of human essential hypertension, at least in the early stages.

Key words: hypertension, essential • prostaglandins • lipid peroxidation • oxidative stress • blood pressure monitoring, ambulatory

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