Published Online
on February 3, 2003

A more recent version of this article appeared on March 1, 2003

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Submitted on September 19, 2002
Revised on October 28, 2002

Adult Rabbit Offspring of Mothers With Secondary Hypertension Have Increased Blood Pressure

Kate M. Denton^*; Rebecca L. Flower; Kathleen M. Stevenson; and Warwick P. Anderson

From the Department of Physiology, Monash University, Victoria, Australia.

^* To whom correspondence should be addressed. E-mail: kate.denton{at}med.monash.edu.au.

Abstract--Preexisting chronic hypertension complicates up to 5% of pregnancies and is associated with an increased risk of low-birth-weight babies. Studies suggest that an adverse intrauterine environment leading to low birth weight is linked to an increased risk of cardiovascular disease, including hypertension, in the adult. In this study, the blood pressure of offspring from mothers with hypertension were followed up into adulthood. Two-kidney, 1-wrapped hypertension was induced in 7 female rabbits; 5 other rabbits underwent sham surgery. Four weeks later, rabbits were mated, at which time mean arterial pressure was 118±3 and 87±5 mm Hg in the hypertensive and sham groups, respectively (P<0.001). The blood pressure of 30-week-old females was 89±2 mm Hg in the offspring of hypertensive (n=14) and 79±1 mm Hg in the offspring of normotensive (n=13) mothers (P<0.005). Also, plasma renin activity was significantly lower in the female offspring of hypertensive mothers at 10 weeks of age (P<0.05), suggesting that development of the renin-angiotensin system was altered. In contrast, male offspring from hypertensive and normotensive mothers had similar mean arterial pressure and plasma renin activity. In conclusion, maternal secondary hypertension can "program" hypertension in female adult offspring. The results also suggest that there are gender-specific differences in sensitivity to altered in utero environmental influences.

Key words: blood pressure • rabbits • hypertension, secondary • pregnancy • renin • gender

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