on February 17, 2003
Published online before print February 17, 2003, doi: 10.1161/01.HYP.0000056996.25503.F5
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Submitted on October 30, 2002
From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash. * To whom correspondence should be addressed. E-mail: Chun-Fang.Qiu{at}Swedish.org.
Abstract--In a case-control study of 190 preeclamptic patients and 373 control subjects, we assessed maternal family history of chronic hypertension and type 2 diabetes in relation to preeclampsia risk. Participants provided information on first-degree family history of the 2 conditions and other covariates during postpartum interviews. Logistic regression was used to estimate odds ratios and 95% confidence intervals adjusted for confounding by age, race, and obesity. Compared with women with no parental history of hypertension, women with maternal only (odds ratio=1.9), paternal only (odds ratio=1.8), or both maternal and paternal history of hypertension (odds ratio=2.6) had a statistically significant increased risk of preeclampsia. The odds ratio for women with at least one hypertensive parent and a hypertensive sibling was 4.7 (95% confidence interval, 1.9 to 11.6). Both maternal only (odds ratio=2.1; 95% confidence interval, 0.9 to 4.6) and paternal only (odds ratio=1.9; 95% confidence interval, 1.0 to 3.2) history of diabetes was associated with an increased risk of preeclampsia. Women with a diabetic sibling had a 4.7-fold increased risk of preeclampsia (95% confidence interval, 1.1 to 19.8). For women with at least one hypertensive parent and at least one diabetic parent, relative to those with parents with neither diagnosis, the odds ratio for preeclampsia was 3.2 (95% confidence interval, 1.6 to 6.2). Our results are consistent with the thesis that family history of hypertension and diabetes reflects genetic and behavioral factors whereby women may be predisposed to an increased preeclampsia risk.
Revised on December 18, 2002
Family History of Hypertension and Type 2 Diabetes in Relation to Preeclampsia Risk
Chunfang Qiu*;
Key words: hypertension, chronic • diabetes mellitus • preeclampsia • pregnancy
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