on September 15, 2003
Published online before print September 15, 2003, doi: 10.1161/01.HYP.0000091370.83602.E6
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Submitted on May 20, 2003
From the Laboratories for Cardiovascular Research, Hebrew Rehabilitation Center for Aged Research and Training Institute (R.D.L., J.K.S., J.A.T.), and the Division on Aging, Harvard Medical School (R.D.L., J.A.T.), Boston, Mass. * To whom correspondence should be addressed. E-mail: ataylor{at}mail.hrca.harvard.edu.
Abstract--Spontaneously occurring, parallel fluctuations in arterial pressure and heart period are frequently used as indices of baroreflex function. Despite the convenience of spontaneous indices, their relation to the arterial baroreflex remains unclear. Therefore, in 97 volunteers, we derived 5 proposed indices (sequence method,
Revised on June 9, 2003
Spontaneous Indices Are Inconsistent With Arterial Baroreflex Gain
Ruth D. Lipman;
-index, transfer function, low-frequency transfer function, and impulse response function), compared them with arterial baroreflex gain (by the modified Oxford pharmacologic technique), and examined their relation to carotid distensibility and respiratory sinus arrhythmia. The subjects comprised men and women (n=41) aged 25 to 86 years, 30% of whom had established coronary artery disease. Generally, the indices were correlated with each other (except -index and low-frequency transfer function) and with baroreflex gain. However, the Bland-Altman method demonstrated that the spontaneous indices had limits of agreement as large as the baroreflex gain itself. Even in individuals within the lowest tertile of baroreflex gain for whom baroreflex gain appears to be the most clinically relevant, spontaneous indices failed to relate to baroreflex gain. In fact, for these individuals, there was no correlation between any index and baroreflex gain. Forward stepwise linear regression showed that all spontaneous indices and baroreflex gain were related to respiratory sinus arrhythmia, but only baroreflex gain was related to carotid distensibility. Therefore, these data suggest that spontaneous indices are inadequate estimates of gain and are inconsistent with arterial baroreflex function.
Key words: baroreceptors • carotid sinus • elasticity • arrhythmia • baroreflex
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