on December 29, 2003
Published online before print December 29, 2003, doi: 10.1161/01.HYP.0000111829.46090.92
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on August 26, 2003
From the Institute for Cardiovascular Research (M.T.S., R.M.A.H., R.A.J.M.v.D., N.W., C.D.A.S.), the Department of Internal Medicine (M.T.S., C.D.A.S.), the Institute for Research in Extramural Medicine (R.M.A.H., P.J.K., J.M.D., G.N., R.J.H.), the Department of Radiology (R.A.J.M.v.D.), the Department of Clinical Epidemiology and Biostatistics (P.J.K.), the Department of Endocrinology (R.J.H.), and the Department of Physiology (N.W.), VU University Medical Center, Amsterdam, The Netherlands. * To whom correspondence should be addressed. E-mail: cda.stehouwer{at}vumc.nl.
Abstract--Impaired glucose metabolism (IGM) and type 2 diabetes (DM-2) are associated with high cardiovascular disease risk. Increases in peripheral and central artery stiffness may represent pathophysiologic pathways through which glucose tolerance status leads to cardiovascular disease. Peripheral artery stiffness increases with deteriorating glucose tolerance status, whereas this trend remains unclear for central artery stiffness. Therefore, we investigated the associations between glucose tolerance status and estimates of central arterial stiffness. We performed a population-based study of 619 individuals (normal glucose metabolism, n=261; IGM, n=170; and DM-2, n=188) and assessed central artery stiffness by measuring total systemic arterial compliance, aortic pressure augmentation index, and carotid-femoral transit time. After adjustment for sex, age, heart rate, height, body mass index, and mean arterial pressure, DM-2 was associated with decreased total systemic arterial compliance, increased aortic augmentation index, and decreased carotid-femoral transit time. IGM was borderline significantly associated with decreased total systemic arterial compliance. Respective regression coefficients (95% confidence intervals) for IGM and DM-2 compared with normal glucose metabolism were -0.05 (-0.11 to 0.01) and -0.13 (-0.19 to -0.07) mL/mm Hg for total systemic arterial compliance; 1.1 (-0.2 to 2.5) and 1.6 (0.2 to 3.0) percentage points for aortic augmentation index; and -0.85 (-5.20 to 3.49) and -4.95 (-9.41 to -0.48) ms for carotid-femoral transit time. IGM and DM-2 are associated with increased central artery stiffness, which is more pronounced in DM-2. Deteriorating glucose tolerance is associated with increased central and peripheral arterial stiffness, which may partly explain why both DM-2 and IGM are associated with increased cardiovascular risk.
Revised on September 12, 2003
Increased Central Artery Stiffness in Impaired Glucose Metabolism and Type 2 Diabetes. The Hoorn Study
Miranda T. Schram;
Key words: diabetes mellitus • arteries • compliance • vascular resistance • total peripheral resistance
This article has been cited by other articles:
 |
|
 |
|
  M. Hornum, P. Clausen, J. Kjaergaard, J. M. Hansen, E. R. Mathiesen, and B. Feldt-Rasmussen Pre-diabetes and arterial stiffness in uraemic patients Nephrol. Dial. Transplant., October 21, 2009; (2009) gfp558v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Nilsson, P. Boutouyrie, and S. Laurent Vascular Aging: A Tale of EVA and ADAM in Cardiovascular Risk Assessment and Prevention Hypertension, July 1, 2009; 54(1): 3 - 10. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Rerkpattanapipat, R. B. D'Agostino Jr, K. M. Link, E. Shahar, J. A. Lima, D. A. Bluemke, S. Sinha, D. M. Herrington, and W. G. Hundley Location of Arterial Stiffening Differs in Those With Impaired Fasting Glucose Versus Diabetes: Implications for Left Ventricular Hypertrophy From the Multi-Ethnic Study of Atherosclerosis Diabetes, April 1, 2009; 58(4): 946 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M B Snijder, A Flyvbjerg, C D A Stehouwer, J Frystyk, R M A Henry, J C Seidell, R J Heine, and J M Dekker Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study Eur. J. Endocrinol., March 1, 2009; 160(3): 387 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. G. Ketel, C. D. A. Stehouwer, E. H. Serne, T. J. M. Korsen, P. G. A. Hompes, Y. M. Smulders, R. T. de Jongh, R. Homburg, and C. B. Lambalk Obese But Not Normal-Weight Women with Polycystic Ovary Syndrome Are Characterized by Metabolic and Microvascular Insulin Resistance J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3365 - 3372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Nakae, S. Matsuo, T. Matsumoto, K. Mitsunami, and M. Horie Augmentation Index and Pulse Wave Velocity as Indicators of Cardiovascular Stiffness Angiology, August 1, 2008; 59(4): 421 - 426. [Abstract] [PDF]
|
|
|
|
 |
|
 A. J. Sommerfield, I. B. Wilkinson, D. J. Webb, and B. M. Frier Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1274 - E1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M.H. Hermans, R. Henry, J. M. Dekker, J. P. Kooman, P. J. Kostense, G. Nijpels, R. J. Heine, and C. D.A. Stehouwer Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness: The Hoorn Study J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1942 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Kullo and A. R. Malik Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1413 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Lee, C. Shirodaria, C. E Jackson, M. D Robson, C. Antoniades, J. M Francis, F. Wiesmann, K. M Channon, S. Neubauer, and R. P Choudhury Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus Diabetes and Vascular Disease Research, March 1, 2007; 4(1): 44 - 48. [Abstract] [PDF]
|
|
|
|
|
|
E. J. Diamantopoulos, E. A. Andreadis, G. I. Tsourous, P. M. Katsanou, D. X. Georgiopoulos, G. D. Dimitriadis, and S. A. Raptis Intermediate Postchallenge Hyperglycemia in Overweight and Obese Subjects: A New Marker of Impaired Glucose Regulation? Angiology, January 1, 2007; 57(6): 709 - 716. [Abstract] [PDF]
|
|
|
|
 |
|
 T. L. Broderick J Appl Physiol, December 1, 2006; 101(6): 1816 - 1817. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Vlachopoulos, K Aznaouridis, and C Stefanadis Clinical appraisal of arterial stiffness: the Argonauts in front of the Golden Fleece Heart, November 1, 2006; 92(11): 1544 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Barinas-Mitchell, L. H. Kuller, K. Sutton-Tyrrell, R. Hegazi, P. Harper, J. Mancino, and D. E. Kelley Effect of Weight Loss and Nutritional Intervention on Arterial Stiffness in Type 2 Diabetes Diabetes Care, October 1, 2006; 29(10): 2218 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Huebschmann, J. G. Regensteiner, H. Vlassara, and J. E.B. Reusch Diabetes and Advanced Glycoxidation End Products. Diabetes Care, June 1, 2006; 29(6): 1420 - 1432. [Full Text] [PDF]
|
|
|
|
|
|
M. E. Safar, S. Czernichow, and J. Blacher Obesity, Arterial Stiffness, and Cardiovascular Risk J. Am. Soc. Nephrol., April 1, 2006; 17(4_suppl_2): S109 - S111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P.H. van Wijk, E. J.P. de Koning, M. C. Cabezas, J. Joven, J. op't Roodt, T. J. Rabelink, and A. M. Hoepelman Functional and Structural Markers of Atherosclerosis in Human Immunodeficiency Virus-Infected Patients J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1117 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mahmud and J. Feely Arterial Stiffness Is Related to Systemic Inflammation in Essential Hypertension Hypertension, November 1, 2005; 46(5): 1118 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Harris, J. R. Hutchinson, K. Sachidanandam, M. H. Johnson, A. M. Dorrance, D. W. Stepp, S. C. Fagan, and A. Ergul Type 2 Diabetes Causes Remodeling of Cerebrovasculature via Differential Regulation of Matrix Metalloproteinases and Collagen Synthesis: Role of Endothelin-1 Diabetes, September 1, 2005; 54(9): 2638 - 2644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Sankatsing, S. W. Fouchier, S. de Haan, B. A. Hutten, E. de Groot, J. J.P. Kastelein, and E. S.G. Stroes Hepatic and Cardiovascular Consequences of Familial Hypobetalipoproteinemia Arterioscler Thromb Vasc Biol, September 1, 2005; 25(9): 1979 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Sista, M. K. O'Connell, T. Hinohara, S. S. Oommen, B. E. Fenster, A. J. Glassford, E. A. Schwartz, C. A. Taylor, G. M. Reaven, and P. S. Tsao Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H845 - H851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Roman, R. B. Devereux, J. E. Schwartz, M. D. Lockshin, S. A. Paget, A. Davis, M. K. Crow, L. Sammaritano, D. M. Levine, B.-A. Shankar, et al. Arterial Stiffness in Chronic Inflammatory Diseases Hypertension, July 1, 2005; 46(1): 194 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schillaci, M. Pirro, G. Vaudo, M. R. Mannarino, G. Savarese, G. Pucci, S. S. Franklin, and E. Mannarino Metabolic Syndrome Is Associated With Aortic Stiffness in Untreated Essential Hypertension Hypertension, June 1, 2005; 45(6): 1078 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ferreira, R. M. A. Henry, J. W. R. Twisk, W. van Mechelen, H. C. G. Kemper, and C. D. A. Stehouwer The Metabolic Syndrome, Cardiopulmonary Fitness, and Subcutaneous Trunk Fat as Independent Determinants of Arterial Stiffness: The Amsterdam Growth and Health Longitudinal Study Arch Intern Med, April 25, 2005; 165(8): 875 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakano, K. Konishi, K. Furuya, K. Uehara, M. Nishizawa, A. Nakagawa, T. Kigoshi, and K. Uchida A Prognostic Role of Mean 24-h Pulse Pressure Level for Cardiovascular Events in Type 2 Diabetic Subjects Under 60 Years of Age Diabetes Care, January 1, 2005; 28(1): 95 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Boreham, I. Ferreira, J. W. Twisk, A. M. Gallagher, M. J. Savage, and L. J. Murray Cardiorespiratory Fitness, Physical Activity, and Arterial Stiffness: The Northern Ireland Young Hearts Project Hypertension, November 1, 2004; 44(5): 721 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Tayebjee, H. S. Lim, R. J. MacFadyen, and G. Y.H. Lip Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 and -2 in Type 2 Diabetes: Effect of 1 year's cardiovascular risk reduction therapy Diabetes Care, August 1, 2004; 27(8): 2049 - 2051. [Full Text] [PDF]
|
|