Published Online
on February 16, 2004

A more recent version of this article appeared on April 1, 2004

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Submitted on September 30, 2003
Revised on October 22, 2003

WNK4 Intron 10 Polymorphism Is Not Associated With Hypertension

Helen J.L. Speirs and Brian J. Morris^*

From the Basic & Clinical Genomics Laboratory, School of Medical Sciences and Institute of Biomedical Research, University of Sydney, Australia.

^* To whom correspondence should be addressed. E-mail: brianm{at}physiol.usyd.edu.au.

Abstract--A polymorphism in intron 10 of the serine-threonine kinase with no lysine (K) 4 gene WNK4 (GA, base 1156666 on chromosome 17) has recently been associated with essential hypertension in a white American population. We have attempted to replicate this finding in a well characterized cohort of 184 unrelated hypertensive Australians of British extraction in which biological power was enhanced by them each having 2 hypertensive parents. Controls were 219 normotensive ethnically matched subjects whose parents were both normotensive. Genotyping was performed using the homogeneous MassEXTEND Assay. This showed a frequency of 0.10 for the minor allele in each group (P=0.88). Moreover, blood pressure, body mass index, sex, and plasma lipid levels were similar across genotypes. In conclusion, our study provides no support for an association of the intron 10 variant of WNK4 with essential hypertension in the Anglo-Australian population studied.

Key words: kinase • hypertension, essential • genetics • polymorphism • sodium transport

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