on April 12, 2004
Published online before print April 12, 2004, doi: 10.1161/01.HYP.0000126991.67203.7b
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 15, 2004
From the Center for Reproduction and Early Life (D.S.G., S.P., M.M.R., T.S., M.E.S.), Institute of Clinical Research, University Hospital, Nottingham, United Kingdom, and Schools of Nursing (J.D.) and Biosciences (R.W.), University of Nottingham, United Kingdom. * To whom correspondence should be addressed. E-mail: david.gardner{at}nottingham.ac.uk.
Abstract--An adverse environment around conception and implantation influences later fetal growth and development to term in humans and sheep. Indeed, preimplantation undernutrition of rats elevated the systolic blood pressure of the resultant adult offspring. In this study, adult cardiovascular function is examined in a slower growing, non-litter-bearing species after peri-implantation undernutrition. Eight ewes were fed to 50% equivalent food intake of 12 control ewes from 1 to 30 days (term
Revised on February 29, 2004
Peri-Implantation Undernutrition Programs Blunted Angiotensin II Evoked Baroreflex Responses in Young Adult Sheep
David S. Gardner*;
147 days) only. Following consumption of an adequate diet to term, natural lambing, and then weaning, resting cardiovascular status and baroreflex function were examined in the resultant young adult offspring. Birth weight and postnatal growth to 1 year of age were unaffected by early undernutrition; however, nutrient-restricted sheep had increased pulse pressure, a reduced rate pressure product, and a leftward shift in their baroreflex function curve. Baroreflex sensitivity during angiotensin II infusion was also blunted in early nutrient-restricted sheep but the tachycardia following a reduction in central blood pressure appeared potentiated, relative to controls. The data suggest that peri-implantation undernutrition may program long-term cardiovascular dysfunction that ultimately increases the risk of hypertension later in life. An increase in regional angiotensin II activity during this critical early phase of development is a likely candidate mechanism for the effects observed. The data have broad implications for the health outcome of those offspring from mothers who were poorly nourished during early, often unknown pregnancy and for embryos artificially manipulated because of infertility treatment.
Key words: sheep • angiotensin II • blood pressure • baroreflex
This article has been cited by other articles:
 |
|
 |
|
  C. J. Ashworth, L. M. Toma, and M. G. Hunter Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability Phil Trans R Soc B, November 27, 2009; 364(1534): 3351 - 3361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Cetin, C. Berti, and S. Calabrese Role of micronutrients in the periconceptional period Hum. Reprod. Update, June 30, 2009; (2009) dmp025v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Long, K. A. Vonnahme, B. W. Hess, P. W. Nathanielsz, and S. P. Ford Effects of early gestational undernutrition on fetal growth, organ development, and placentomal composition in the bovine J Anim Sci, June 1, 2009; 87(6): 1950 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sharkey, H. P. Fainberg, V. Wilson, E. Harvey, D. S. Gardner, M. E. Symonds, and H. Budge Impact of Early Onset Obesity and Hypertension on the Unfolded Protein Response in Renal Tissues of Juvenile Sheep Hypertension, June 1, 2009; 53(6): 925 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E Symonds, T. Stephenson, and H. Budge Early determinants of cardiovascular disease: the role of early diet in later blood pressure control Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1518S - 1522S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Burrage, L. Braddick, J. K. Cleal, P. Costello, D. E. Noakes, M. A. Hanson, and L. R. Green The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep J. Physiol., February 1, 2009; 587(3): 611 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pallares and A. Gonzalez-Bulnes Intrauterine Growth Retardation in Endothelial Nitric Oxide Synthase-Deficient Mice Is Established from Early Stages of Pregnancy Biol Reprod, June 1, 2008; 78(6): 1002 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ceelen, M. M. van Weissenbruch, J. P. W. Vermeiden, F. E. van Leeuwen, and H. A. Delemarre-van de Waal Cardiometabolic Differences in Children Born After in Vitro Fertilization: Follow-Up Study J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1682 - 1688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bertram, O. Khan, S. Ohri, D. I. Phillips, S. G. Matthews, and M. A. Hanson Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function J. Physiol., April 15, 2008; 586(8): 2217 - 2229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J Watkins, E. Ursell, R. Panton, T. Papenbrock, L. Hollis, C. Cunningham, A. Wilkins, V. H. Perry, B. Sheth, W. Y. Kwong, et al. Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease Biol Reprod, February 1, 2008; 78(2): 299 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Sinclair, C. Allegrucci, R. Singh, D. S. Gardner, S. Sebastian, J. Bispham, A. Thurston, J. F. Huntley, W. D. Rees, C. A. Maloney, et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status PNAS, December 4, 2007; 104(49): 19351 - 19356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bennet, L. C. Booth, N. Ahmed-Nasef, J. M. Dean, J. Davidson, J. S. Quaedackers, and A. J. Gunn Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1280 - R1286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Husted, M. O. Nielsen, M. P. Tygesen, A. Kiani, D. Blache, and K. L. Ingvartsen Programming of intermediate metabolism in young lambs affected by late gestational maternal undernourishment Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E548 - E557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Cleal, K. R. Poore, J. P. Boullin, O. Khan, R. Chau, O. Hambidge, C. Torrens, J. P. Newman, L. Poston, D. E. Noakes, et al. Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood PNAS, May 29, 2007; 104(22): 9529 - 9533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Watkins, D. Platt, T. Papenbrock, A. Wilkins, J. J. Eckert, W. Y. Kwong, C. Osmond, M. Hanson, and T. P. Fleming From the Cover: Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure PNAS, March 27, 2007; 104(13): 5449 - 5454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Frasch, T. Muller, C. Wicher, C. Weiss, M. Lohle, K. Schwab, H. Schubert, P. W. Nathanielsz, O. W. Witte, and M. Schwab Fetal body weight and the development of the control of the cardiovascular system in fetal sheep J. Physiol., March 15, 2007; 579(3): 893 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jones, A. Beda, A. M.V. Ward, C. Osmond, D. I.W. Phillips, V. M. Moore, and D. M. Simpson Size at Birth and Autonomic Function During Psychological Stress Hypertension, March 1, 2007; 49(3): 548 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D S Gardner, P J Buttery, Z Daniel, and M E Symonds Factors affecting birth weight in sheep: maternal environment Reproduction, January 1, 2007; 133(1): 297 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Poore, J. K. Cleal, J. P. Newman, J. P. Boullin, D. E. Noakes, M. A. Hanson, and L. R. Green Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E32 - E39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C Painter, S. R de Rooij, P. M Bossuyt, T. A Simmers, C. Osmond, D. J Barker, O. P Bleker, and T. J Roseboom Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 322 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D S Gardner, B W M Van Bon, J Dandrea, P J Goddard, S F May, V Wilson, T Stephenson, and M E Symonds Effect of periconceptional undernutrition and gender on hypothalamic-pituitary-adrenal axis function in young adult sheep. J. Endocrinol., August 1, 2006; 190(2): 203 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Polson, N. McCallion, H. Waki, G. Thorne, M. A. Tooley, J. F.R. Paton, and A. R. Wolf Evidence for Cardiovascular Autonomic Dysfunction in Neonates With Coarctation of the Aorta Circulation, June 20, 2006; 113(24): 2844 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Gardner, K. Tingey, B. W. M. Van Bon, S. E. Ozanne, V. Wilson, J. Dandrea, D. H. Keisler, T. Stephenson, and M. E. Symonds Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R947 - R954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kapoor and S. G Matthews Short periods of prenatal stress affect growth, behaviour and hypothalamo-pituitary-adrenal axis activity in male guinea pig offspring J. Physiol., August 1, 2005; 566(3): 967 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. MacLaughlin, S. K. Walker, C. T. Roberts, D. O. Kleemann, and I. C. McMillen Periconceptional nutrition and the relationship between maternal body weight changes in the periconceptional period and feto-placental growth in the sheep J. Physiol., May 15, 2005; 565(1): 111 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Armitage, I. Y Khan, P. D Taylor, P. W Nathanielsz, and L. Poston Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J. Physiol., December 1, 2004; 561(2): 355 - 377. [Abstract] [Full Text] [PDF]
|
|