on May 3, 2004
Hypertension. 2004
Published online before print May 3, 2004, doi: 10.1161/01.HYP.0000129281.03801.4b
Published online before print May 3, 2004, doi: 10.1161/01.HYP.0000129281.03801.4b
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on February 24, 2004
From the Departments of Geriatric Medicine (Y.I., T.K., K.I., M.O., K.S., Y.F., M.M., K.Y., A.M., H.R., T.O.) and Internal Medicine and Molecular Science (N.O., K.O., S.K., T.F., Y.M.), Osaka University Graduate School of Medicine, Japan. * To whom correspondence should be addressed. E-mail: katsuya{at}geriat.med.osaka-u.ac.jp.
Abstract--Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2±0.2 µg/mL; NT: 6.1±0.2 µg/mL; P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6±0.9 µg/mL; TT: 5.5±0.1 µg/mL; P<0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.
Revised on March 9, 2004
Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
Yoshio Iwashima;
Key words: blood pressure • genetics • hypertension, genetic • men • mutation
This article has been cited by other articles:
 |
|
 |
|
  K D Bruce and C D Byrne The metabolic syndrome: common origins of a multifactorial disorder Postgrad. Med. J., November 1, 2009; 85(1009): 614 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Summer, C. A. Fiack, Y. Ikeda, K. Sato, D. Dwyer, N. Ouchi, A. Fine, H. W. Farber, and K. Walsh Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease Am J Physiol Lung Cell Mol Physiol, September 1, 2009; 297(3): L432 - L438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bumrungpert, R. W. Kalpravidh, C. Chitchumroonchokchai, C.-C. Chuang, T. West, A. Kennedy, and M. McIntosh Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes J. Nutr., June 1, 2009; 139(6): 1185 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Denzel, L. W. Hebbard, G. Shostak, L. Shapiro, R. D. Cardiff, and B. Ranscht Adiponectin Deficiency Limits Tumor Vascularization in the MMTV-PyV-mT Mouse Model of Mammary Cancer Clin. Cancer Res., May 15, 2009; 15(10): 3256 - 3264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Laumen, A. D. Saningong, I. M. Heid, J. Hess, C. Herder, M. Claussnitzer, J. Baumert, C. Lamina, W. Rathmann, E.-M. Sedlmeier, et al. Functional Characterization of Promoter Variants of the Adiponectin Gene Complemented by Epidemiological Data Diabetes, April 1, 2009; 58(4): 984 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sacheck Pediatric Obesity: An Inflammatory Condition? JPEN J Parenter Enteral Nutr, November 1, 2008; 32(6): 633 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Aguilar-Salinas, E. G. Garcia, L. Robles, D. Riano, D. G. Ruiz-Gomez, A. C. Garcia-Ulloa, M. A. Melgarejo, M. Zamora, L. E. Guillen-Pineda, R. Mehta, et al. High Adiponectin Concentrations Are Associated with the Metabolically Healthy Obese Phenotype J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 4075 - 4079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Wardaningsih, T. Miida, U. Seino, Y. Fueki, M. Ito, K. Nagasaki, T. Kikuchi, M. Uchiyama, S. Hirayama, O. Hanyu, et al. Low adiponectin state is associated with metabolic abnormalities in obese children, particularly depending on apolipoprotein E phenotype Ann Clin Biochem, September 1, 2008; 45(5): 496 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Teoh, A. Quan, K. W. A. Bang, G. Wang, F. Lovren, V. Vu, J. J. Haitsma, P. E. Szmitko, M. Al-Omran, C.-H. Wang, et al. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E658 - E664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Karmazyn, D. M. Purdham, V. Rajapurohitam, and A. Zeidan Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart Cardiovasc Res, July 15, 2008; 79(2): 279 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Olufadi and C D Byrne Clinical and laboratory diagnosis of the metabolic syndrome J. Clin. Pathol., June 1, 2008; 61(6): 697 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Skurk, F. Wittchen, L. Suckau, H. Witt, M. Noutsias, H. Fechner, H.-P. Schultheiss, and W. Poller Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy Eur. Heart J., May 1, 2008; 29(9): 1168 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Z. Duan, M. G. Usher, and R. M. Mortensen Peroxisome Proliferator-Activated Receptor-{gamma}-Mediated Effects in the Vasculature Circ. Res., February 15, 2008; 102(3): 283 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nishimura, Y. Izumiya, A. Higuchi, R. Shibata, J. Qiu, C. Kudo, H. K. Shin, M. A. Moskowitz, and N. Ouchi Adiponectin Prevents Cerebral Ischemic Injury Through Endothelial Nitric Oxide Synthase-Dependent Mechanisms Circulation, January 15, 2008; 117(2): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. V. Wang and P. E. Scherer Adiponectin, Cardiovascular Function, and Hypertension Hypertension, January 1, 2008; 51(1): 8 - 14. [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Rose, S. M. Haffner, and J. Baillargeon Adiposity, the Metabolic Syndrome, and Breast Cancer in African-American and White American Women Endocr. Rev., December 1, 2007; 28(7): 763 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Femia, M. Kozakova, M. Nannipieri, C. Gonzales-Villalpando, M. P. Stern, S. M. Haffner, and E. Ferrannini Carotid Intima-Media Thickness in Confirmed Prehypertensive Subjects: Predictors and Progression Arterioscler Thromb Vasc Biol, October 1, 2007; 27(10): 2244 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fesus, G. Dubrovska, K. Gorzelniak, R. Kluge, Y. Huang, F. C. Luft, and M. Gollasch Adiponectin is a novel humoral vasodilator Cardiovasc Res, September 1, 2007; 75(4): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Masuyama, H. Nakatsukasa, N. Takamoto, and Y. Hiramatsu Correlation between Soluble Endoglin, Vascular Endothelial Growth Factor Receptor-1, and Adipocytokines in Preeclampsia J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2672 - 2679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mitsuhashi, H. Yatsuya, K. Tamakoshi, K. Matsushita, R. Otsuka, K. Wada, K. Sugiura, S. Takefuji, Y. Hotta, T. Kondo, et al. Adiponectin Level and Left Ventricular Hypertrophy in Japanese Men Hypertension, June 1, 2007; 49(6): 1448 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-S. Chow, B. M.Y. Cheung, A. W.K. Tso, A. Xu, N. M.S. Wat, C. H.Y. Fong, L. H.Y. Ong, S. Tam, K. C.B. Tan, E. D. Janus, et al. Hypoadiponectinemia as a Predictor for the Development of Hypertension: A 5-Year Prospective Study Hypertension, June 1, 2007; 49(6): 1455 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schillaci and M. Pirro Hypoadiponectinemia: A Novel Link Between Obesity and Hypertension? Hypertension, June 1, 2007; 49(6): 1217 - 1219. [Full Text] [PDF]
|
|
|
|
|
|
C. Menzaghi, V. Trischitta, and A. Doria Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease Diabetes, May 1, 2007; 56(5): 1198 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Szmitko, H. Teoh, D. J. Stewart, and S. Verma Adiponectin and cardiovascular disease: state of the art? Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1655 - H1663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc Res, April 1, 2007; 74(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Han, M. J. Quon, J.-a Kim, and K. K. Koh Adiponectin and Cardiovascular Disease: Response to Therapeutic Interventions J. Am. Coll. Cardiol., February 6, 2007; 49(5): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sharma, I. C. Okere, M. K. Duda, D. J. Chess, K. M. O'Shea, and W. C. Stanley Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy Cardiovasc Res, January 15, 2007; 73(2): 257 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mitsnefes, J. Kartal, P. Khoury, and S. Daniels Adiponectin in Children with Chronic Kidney Disease: Role of Adiposity and Kidney Dysfunction Clin. J. Am. Soc. Nephrol., January 1, 2007; 2(1): 46 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Hegener, I-M. Lee, N. R. Cook, P. M. Ridker, and R. Y.L. Zee Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study Clin. Chem., November 1, 2006; 52(11): 2021 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fry, P. M. Smith, T. D. Hoyda, M. Duncan, R. S. Ahima, K. A. Sharkey, and A. V. Ferguson Area postrema neurons are modulated by the adipocyte hormone adiponectin. J. Neurosci., September 20, 2006; 26(38): 9695 - 9702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohashi, S. Kihara, N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, et al. Adiponectin Replenishment Ameliorates Obesity-Related Hypertension Hypertension, June 1, 2006; 47(6): 1108 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Heid, S. A. Wagner, H. Gohlke, B. Iglseder, J. C. Mueller, P. Cip, G. Ladurner, R. Reiter, A. Stadlmayr, V. Mackevics, et al. Genetic Architecture of the APM1 Gene and Its Influence on Adiponectin Plasma Levels and Parameters of the Metabolic Syndrome in 1,727 Healthy Caucasians Diabetes, February 1, 2006; 55(2): 375 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Efstathiou, D. I. Tsioulos, A. G. Tsiakou, Y. E. Gratsias, A. V. Pefanis, and T. D. Mountokalakis Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke Stroke, September 1, 2005; 36(9): 1915 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Iwashima, T. Katsuya, K. Ishikawa, I. Kida, M. Ohishi, T. Horio, N. Ouchi, K. Ohashi, S. Kihara, T. Funahashi, et al. Association of Hypoadiponectinemia With Smoking Habit in Men Hypertension, June 1, 2005; 45(6): 1094 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-P. Chen, J. C.-R. Tsai, F.-M. Chung, S.-S. Yang, L.-L. Hsing, S.-J. Shin, and Y.-J. Lee Hypoadiponectinemia Is Associated With Ischemic Cerebrovascular Disease Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 821 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S G Kim, H Y Kim, J A Seo, K W Lee, J H Oh, N H Kim, K M Choi, S H Baik, and D S Choi Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease Eur. J. Endocrinol., February 1, 2005; 152(2): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Yilmaz, A. Sonmez, S. Kilic, T. Celik, N. Bingol, M. Pinar, T. Mumcuoglu, and M. Ozata The association of plasma adiponectin levels with hypertensive retinopathy Eur. J. Endocrinol., February 1, 2005; 152(2): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rahmouni, M. L.G. Correia, W. G. Haynes, and A. L. Mark Obesity-Associated Hypertension: New Insights Into Mechanisms Hypertension, January 1, 2005; 45(1): 9 - 14. [Abstract] [Full Text] [PDF]
|
|