on September 13, 2004
Published online before print September 13, 2004, doi: 10.1161/01.HYP.0000143483.66701.ec
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on May 16, 2004
From the Universidad Autónoma de Bucaramanga (N.C.S., L.A.D., C.P.), Colombia; Centre for Clinical Pharmacology (J.P.C., A.D.H., P.V.), Department of Medicine, BHF Laboratories at University College London (UCL), United Kingdom; Instituto de Ciencias de la Salud, Colombia (C.M.M.); Universidad del Valle (R.C.), Colombia; Universidad de Cartagena, Colombia (A.M.); Universidad Nacional de Colombia (A.B.), Colombia; Centre for Cardiovascular Genetics (E.H.), Department of Medicine, British Heart Foundation Laboratories at UCL; Instituto Colombiano de Investigaciones Biomédicas (P.L.-J.), Colombia; and Fundación Cardiovascular del Oriente Colombiano, Colombia (P.L.-J.). * To whom correspondence should be addressed. E-mail: nserrano{at}unab.edu.co.
Abstract--Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting. We assessed whether eNOS genotypes alter the risk of preeclampsia in a population in which the incidence of this disorder is high. A total of 844 young pregnant women (322 preeclamptic and 522 controls) were recruited from 5 cities. Genotyping for the Glu298Asp, intron-4 and -786T
Revised on June 8, 2004
Endothelial NO Synthase Genotype and Risk of Preeclampsia. A Multicenter Case-Control Study
Norma C. Serrano*;
C polymorphisms in the eNOS gene was conducted. Multivariate odds ratios (ORs) were obtained to estimate the association of individual polymorphisms and haplotypes with preeclampsia risk. No increase in the risk of preeclampsia for the intron-4 or -786TC polymorphisms was observed under any model of inheritance. In contrast, in women homozygous for the Asp298 allele, the adjusted OR for preeclampsia was 4.60 (95% confidence interval [CI], 1.73 to 12.22) compared with carriers of the Glu298 allele. After a multivariate analysis, carriage of the "Asp298-786C-4b" haplotype was also associated with increased risk of preeclampsia (OR, 2.11 [95% CI, 1.33 to 3.34]) compared with carriers of the "Glu298-786T-4b" haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia.
Key words: preeclampsia • nitric oxide synthase • polymorphism • haplotypes • case-control studies
This article has been cited by other articles:
 |
|
 |
|
  P. Lopez-Jaramillo, W. D. Arenas, R. G. Garcia, M. Y. Rincon, and M. Lopez Review: The role of the L-arginine-nitric oxide pathway in preeclampsia Therapeutic Advances in Cardiovascular Disease, August 1, 2008; 2(4): 261 - 275. [Abstract] [PDF]
|
|
|
|
 |
|
 B. D. LaMarca, J. Gilbert, and J. P. Granger Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia Hypertension, April 1, 2008; 51(4): 982 - 988. [Full Text] [PDF]
|
|
|
|
|
|
A. M. Germain, M. C. Romanik, I. Guerra, S. Solari, M. S. Reyes, R. J. Johnson, K. Price, S. A. Karumanchi, and G. Valdes Endothelial Dysfunction: A Link Among Preeclampsia, Recurrent Pregnancy Loss, and Future Cardiovascular Events? Hypertension, January 1, 2007; 49(1): 90 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Casas, G. L. Cavalleri, L. E. Bautista, L. Smeeth, S. E. Humphries, and A. D. Hingorani Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review Am. J. Epidemiol., November 15, 2006; 164(10): 921 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kulandavelu, D. Qu, and S. L. Adamson Cardiovascular Function in Mice During Normal Pregnancy and in the Absence of Endothelial NO Synthase Hypertension, June 1, 2006; 47(6): 1175 - 1182. [Abstract] [Full Text] [PDF]
|
|