Published Online
on October 4, 2004

A more recent version of this article appeared on December 1, 2004

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Submitted on June 9, 2004
Revised on July 2, 2004

Plasma cGMP and Large Artery Remodeling in Asymptomatic Men

Marie-Aude Devynck; Alain Simon^*; Marie-Gabrielle Pernollet; Gilles Chironi; Jérôme Gariepy; Francine Rendu; and Jaime Levenson

From the Centre de Médecine Préventive Cardiovasculaire, UNR-CNRS 7131, Hôpital Broussais, Assistance Publique-Hôpitaux de Paris, Université Paris 5, France.

^* To whom correspondence should be addressed. E-mail: alain.simon{at}brs.ap-hop-paris.fr.

Abstract--cGMP regulates vascular smooth muscle tone and arterial wall response to proliferative signals. We determined plasma cGMP and carotid artery intima-media thickness (IMT) and diameter in 84 asymptomatic men submitted to investigation of their cardiovascular risk profiles. Plasma cGMP was positively associated with IMT (P<0.01) and diameter (P<0.05), independently of coexisting risk factors. These associations were reinforced in the subgroup of subjects with high-sensitivity C-reactive protein level or multiple atherosclerotic plaques. A positive relationship existed between diameter and IMT (P<0.01) and disappeared after cGMP adjustment. This suggests a link between cGMP pathway and arterial wall geometry that is revealed by vascular injury conditions and may participate in early large artery remodeling.

Key words: atherosclerosis • nitric oxide • endothelium • arteries • remodeling • cyclic GMP

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