Published Online
on April 25, 2005

A more recent version of this article appeared on July 1, 2005

This Article Full Text (PDF) All Versions of this Article: 46/1/232    most recent 01.HYP.0000164574.60279.bav1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schram, M. T. Search for Related Content PubMed PubMed Citation Articles by Schram, M. T. Related Collections Pathophysiology Type 1 diabetes Epidemiology Other Vascular biology

Submitted on February 2, 2005
Revised on February 24, 2005

Advanced Glycation End Products Are Associated With Pulse Pressure in Type 1 Diabetes. The EURODIAB Prospective Complications Study

Miranda T. Schram; Casper G. Schalkwijk^*; Aart H. Bootsma; John H. Fuller; Nish Chaturvedi; Coen D.A. Stehouwer; EURODIAB Prospective Complications Study Group

From the Department of Internal Medicine (M.T.S., A.H.B.), Erasmus Medical Center, Rotterdam, the Netherlands; Departments of Internal Medicine (M.T.S., C.D.A.S.) and Clinical Chemistry (C.G.S.), VU University MC, Amsterdam, the Netherlands; Department of Epidemiology and Public Health (J.H.F.), University College, London, UK; International Centre for Circulatory Health and National Heart and Lung Institute (N.C.), Imperial College, London, UK; and Department of Medicine (C.D.A.S.), Academic Hospital Maastricht, the Netherlands.

Abstract--We investigated the associations of pulse pressure (a measure of arterial stiffness) with the early glycation products hemoglobin A1c (HbA1c) and Amadori albumin and the advanced glycation end products pentosidine, N-(carboxymethyl)lysine and N-(carboxyethyl)lysine in a large group of type 1 diabetic individuals of the EURODIAB Prospective Complications Study. We did a cross-sectional nested case-control study from the EURODIAB Prospective Complications Study of 543 (278 men) European individuals with type 1 diabetes diagnosed at <36 years of age. We used linear regression analyses to investigate the association of pulse pressure with glycation products. Pulse pressure was significantly associated with plasma levels of N-(carboxymethyl)lysine and N-(carboxyethyl)lysine but not with HbA1c, Amadori albumin, and urinary levels of pentosidine. Regression coefficients adjusted for age, sex, mean arterial pressure, and duration of diabetes were 0.09 mm Hg (P=0.003) per 1 µM/M lysine N-(carboxymethyl)lysine; 0.24 mm Hg (P=0.001) and -0.03 mm Hg (P=0.62) per 1 µM/M lysine N-(carboxyethyl)lysine (in individuals with and without complications, respectively; P interaction=0.002); and 0.50 mm Hg (P=0.16) per 1% HbA1c; 0.07 mm Hg (P=0.12) per 1 U/mL Amadori albumin; and 0.77 mm Hg (P=0.48) per 1 nmol/mmol creatinine pentosidine. In young type 1 diabetic individuals, arterial stiffness is strongly associated with the advanced glycation end products N-(carboxymethyl)lysine and N-(carboxyethyl)lysine. These findings suggest that the formation of advanced glycation end products is an important pathway in the development of arterial stiffness in young type 1 diabetic individuals.

Key words: diabetes mellitus • arteriosclerosis • elasticity • aging

This article has been cited by other articles:

				M. Dalal, L. Ferrucci, K. Sun, J. Beck, L. P. Fried, and R. D. Semba Elevated Serum Advanced Glycation End Products and Poor Grip Strength in Older Community-Dwelling Women J Gerontol A Biol Sci Med Sci, January 31, 2009; (2009) gln018v1. [Abstract] [Full Text] [PDF]

				N. Bjarnegard, H. J Arnqvist, T.;r. Lindstro;m, L. Jonasson, and T. Lanne Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus Diabetes and Vascular Disease Research, January 1, 2009; 6(1): 25 - 31. [Abstract] [PDF]

				G. Gruden, G. Bruno, N. Chaturvedi, D. Burt, C. Schalkwijk, S. Pinach, C. D. Stehouwer, D. R. Witte, J. H. Fuller, P. C. Perin, et al. Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study: A Novel Circulating Marker for Diabetic Neuropathy Diabetes, July 1, 2008; 57(7): 1966 - 1970. [Abstract] [Full Text] [PDF]

				P. Faure, R. Tamisier, J-P. Baguet, A. Favier, S. Halimi, P. Levy, and J-L. Pepin Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome Eur. Respir. J., May 1, 2008; 31(5): 1046 - 1053. [Abstract] [Full Text] [PDF]

				J.-C. Philips, M. Marchand, and A. J. Scheen Squatting Amplifies Pulse Pressure Increase With Disease Duration in Patients With Type 1 Diabetes Diabetes Care, February 1, 2008; 31(2): 322 - 324. [Abstract] [Full Text] [PDF]

				S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]

				M. A. Roberts, M. C. Thomas, D. Fernando, N. Macmillan, D. A. Power, and F. L. Ierino Low molecular weight advanced glycation end products predict mortality in asymptomatic patients receiving chronic haemodialysis Nephrol. Dial. Transplant., June 1, 2006; 21(6): 1611 - 1617. [Abstract] [Full Text] [PDF]