Published Online
on April 18, 2005

A more recent version of this article appeared on May 1, 2005

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Submitted on January 15, 2005
Revised on January 29, 2005

Elevated C-Reactive Protein Augments Increased Arterial Stiffness in Subjects With the Metabolic Syndrome

Hirofumi Tomiyama; Yutaka Koji; Minoru Yambe; Kohki Motobe; Kazuki Shiina; Zaydun Gulnisa; Yoshio Yamamoto; and Akira Yamashina^*

From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.

^* To whom correspondence should be addressed. E-mail: akyam{at}tokyo-med.ac.jp.

Abstract--We examined whether the presence of an increasing number of metabolic syndrome "disorders" was associated with an increasing pulse wave velocity, which is recognized as a marker of cardiovascular risk, and evaluated whether an elevated plasma C-reactive protein level augments this increasing pulse wave velocity. Using a cross-sectional study design, C-reactive protein, metabolic syndrome-related anthropometric parameters, and pulse wave velocity were measured in 5752 middle-aged Japanese men (44±10 years old). In linear regression analyses, all of the metabolic "disorders" and the logarithm of the C-reactive protein significantly correlated with pulse wave velocity. Multiple linear regression analysis demonstrated that triglycerides, HDL cholesterol, mean blood pressure, fasting glucose, and the logarithm of the C-reactive protein were significant independent positive predictors of pulse wave velocity (R-square=0.38). The presence of an increasing number of metabolic "disorders" in the subjects was associated with an increasing pulse wave velocity (no disorders 1228±139 cm/s 3 disorders 1437±250 cm/s; P<0.01). Among subjects with the metabolic syndrome, pulse wave velocity was higher in cases with (1508±278 cm/s) than in those without an elevated C-reactive protein (1427±243 cm/s; P<0.01). In conclusion, an increase in arterial stiffness may constitute a pathophysiological basis for the increased risk of cardiovascular disease in patients with the metabolic syndrome and that an elevated C-reactive protein level may aggravate this cardiovascular risk.

Key words: arteriosclerosis • hypertension, obesity • immune systems • insulin resistance

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