Published Online
on June 13, 2005

A more recent version of this article appeared on July 1, 2005

This Article Full Text (PDF) All Versions of this Article: 46/1/71    most recent 01.HYP.0000171475.40259.d1v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sanders, M. W. Articles by De Mey, J. G.R. Search for Related Content PubMed PubMed Citation Articles by Sanders, M. W. Articles by De Mey, J. G.R. Related Collections Animal models of human disease Other hypertension Other Treatment Other Research

Submitted on February 28, 2005
Revised on March 16, 2005

High Sodium Intake Increases Blood Pressure and Alters Renal Function in Intrauterine Growth-Retarded Rats

Marijke W. Sanders; Gregorio E. Fazzi; Ger M.J. Janssen; Carlos E. Blanco; and Jo G.R. De Mey^*

From the Department of Pharmacology and Toxicology (M.W.S., G.E.F., G.M.J.J., J.G.R.D.), Cardiovascular Research Institute Maastricht; and School of Life Sciences, Transnational University of Limburg and Department of Pediatrics (C.E.B.), University of Maastricht, The Netherlands.

^* To whom correspondence should be addressed. E-mail: j.demey{at}farmaco.unimaas.nl.

Abstract--A suboptimal fetal environment increases the risk to develop cardiovascular disease in the adult. We reported previously that intrauterine stress in response to reduced uteroplacental blood flow in the pregnant rat limits fetal growth and compromises renal development, leading to an altered renal function in the adult offspring. Here we tested the hypothesis that high dietary sodium intake in rats with impaired renal development attributable to intrauterine stress, results in increased blood pressure, altered renal function, and organ damage. In rats, intrauterine stress was induced by bilateral ligation of the uterine arteries at day 17 of pregnancy. At the age of 12 weeks, the offspring was given high-sodium drinking water (2% sodium chloride). At the age of 16 weeks, rats were instrumented for monitoring of blood pressure and renal function. After intrauterine stress, litter size and birth weight were reduced, whereas hematocrit at birth was increased. Renal blood flow, glomerular filtration rate, and the glomerular filtration fraction were increased significantly after intrauterine stress. High sodium intake did not change renal function and blood pressure in control animals. However, during high sodium intake in intrauterine stress offspring, renal blood flow, glomerular filtration rate, and the filtration fraction were decreased, and blood pressure was increased. In addition, these animals developed severe albuminuria, an important sign of renal dysfunction. Thus, a suboptimal fetal microenvironment, which impairs renal development, results in sodium-dependent hypertension and albuminuria.

Key words: hypertension, sodium-dependent • sodium

This article has been cited by other articles:

				F. Boubred, L. Daniel, C. Buffat, J.-M. Feuerstein, M. Tsimaratos, C. Oliver, F. Dignat-George, M. Lelievre-Pegorier, and U. Simeoni Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats Am J Physiol Renal Physiol, October 1, 2009; 297(4): F943 - F951. [Abstract] [Full Text] [PDF]

				J. P. Porter, S. H. King, and A. D. Honeycutt Prenatal high-salt diet in the Sprague-Dawley rat programs blood pressure and heart rate hyperresponsiveness to stress in adult female offspring Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R334 - R342. [Abstract] [Full Text] [PDF]

				S. P. Bagby Maternal Nutrition, Low Nephron Number, and Hypertension in Later Life: Pathways of Nutritional Programming J. Nutr., April 1, 2007; 137(4): 1066 - 1072. [Abstract] [Full Text] [PDF]

				M. Bursztyn, M.-L. Gross, T. Goltser-Dubner, N. Koleganova, T. Birman, Y. Smith, and I. Ariel Adult Hypertension in Intrauterine Growth-Restricted Offspring of Hyperinsulinemic Rats: Evidence of Subtle Renal Damage Hypertension, October 1, 2006; 48(4): 717 - 723. [Abstract] [Full Text] [PDF]

				E. Ritz Salt--friend or foe? Nephrol. Dial. Transplant., August 1, 2006; 21(8): 2052 - 2056. [Full Text] [PDF]

				J. C. G. Magalhaes, A. B. da Silveira, D. L. Mota, and A. D. O. Paixao Renal function in juvenile rats subjected to prenatal malnutrition and chronic salt overload Exp Physiol, May 1, 2006; 91(3): 611 - 619. [Abstract] [Full Text] [PDF]

				K. Zandi-Nejad, V. A. Luyckx, and B. M. Brenner Adult Hypertension and Kidney Disease: The Role of Fetal Programming Hypertension, March 1, 2006; 47(3): 502 - 508. [Abstract] [Full Text] [PDF]