Published Online
on October 24, 2005

A more recent version of this article appeared on December 1, 2005

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Submitted on March 29, 2005
Revised on April 13, 2005

Uric Acid Is as Important as Proteinuria in Identifying Fetal Risk in Women With Gestational Hypertension

James M. Roberts^*; Lisa M. Bodnar; Kristine Y. Lain; Carl A. Hubel; Nina Markovic; Roberta B. Ness; and Robert W. Powers

From the Departments of Obstetrics, Gynecology and Reproductive Sciences (J.M.R., K.Y.L., C.A.H., R.B.N., R.W.P.), Epidemiology (J.M.R., L.M.B.), and Dental Medicine (N.M.), Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pa

^* To whom correspondence should be addressed. E-mail: rsijmr{at}mwri.magee.edu.

Abstract--Gestational hypertension is differentiated into higher and lower risk by the presence or absence of proteinuria. We asked if hyperuricemia, a common finding in pregnancy hypertension, might also be an indicator of increased risk. We examined fetal outcome data from 972 pregnancies collected from 1997 to 2002 in a nested case-control study. Participants were nulliparous with no known medical complications. The frequency of preterm birth, the duration of pregnancy, frequency of small-for-gestational-age infants, and birth weight centile were determined for pregnancies assigned to 8 categories by the presence or absence of combinations of hypertension, hyperuricemia, and proteinuria. In women with gestational hypertension, hyperuricemia was associated with shorter gestations and smaller birth weight centiles and increased risk of preterm birth and small-for-gestational-age infants. Hyperuricemia increased the risk of these outcomes in the presence or absence of proteinuria. Risk was also increased in a small group of women with hyperuricemia and proteinuria without hypertension. Women with only hypertension and hyperuricemia have similar or greater risk as women with only hypertension and proteinuria. Those with hypertension, proteinuria, and hyperuricemia have greater risk than those with hypertension and proteinuria alone. The risk of these outcomes increased with increasing uric acid. Hyperuricemia is at least as effective as proteinuria at identifying gestational hypertensive pregnancies at increased risk. Uric acid should be reexamined for clinical and research utility.

Key words: gestational hypertension • preeclampsia • pregnancy • uric acid • intrauterine growth restriction • preterm birth • risk assessment

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