Published Online
on December 19, 2005

A more recent version of this article appeared on March 1, 2006

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Submitted on September 15, 2005
Revised on October 6, 2005

Views of the Renin-Angiotensin System. Brilling, Mimsy, and Slithy Tove

Kenneth E. Bernstein^*

From the Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Ga.

^* To whom correspondence should be addressed. E-mail: kbernst{at}emory.edu.

Abstract--The renin-angiotensin system plays a role in many physiological systems, as proven by the phenotype of angiotensin-converting enzyme (ACE) knockout mice. We have used homologous recombination to create novel lines of mice with limited and unusual expression patterns of ACE. These mice show that, as long as an animal can regulate renin, they can tolerate both unusual patterns and reduced expression of ACE. We have also created mice in which one of the two ACE catalytic sites is nonfunctional. These new lines of mice give great insight into the function of the renin-angiotensin system in blood pressure control, response to stress, hematopoiesis, and reproduction.

Key words: angiotensin • angiotensin-converting enzyme • renin • mice • blood pressure • renin-angiotensin system

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