Published Online
on December 19, 2005

A more recent version of this article appeared on March 1, 2006

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Submitted on September 16, 2005
Revised on October 12, 2005

Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7). An Evolving Story in Cardiovascular Regulation

Carlos M. Ferrario^*

From the Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC.

^* To whom correspondence should be addressed. E-mail: cferrari{at}wfubmc.edu.

Abstract--This lecture summarizes the chronology and rationale that led to the discovery of angiotensin-(1-7) as a hormone that, in its own right, opposes the vasoconstrictor and proliferative actions of angiotensin II. The work discussed here additionally analyzes the newest findings on angiotensin-converting enzyme 2, the angiotensin-converting enzyme homologue that efficiently hydrolyzes angiotensin II into angiotensin-(1-7). Both components of this system may significantly influence our future perspective of the role of the renin-angiotensin system, not just in terms of its role in the regulation of cardiovascular and renal function but, moreover, as regulators of a vast array of disease processes in which inflammation and immune mechanisms play a role.

Key words: hypertension • receptors, angiotensin • angiotensin converting enzyme • angiotensin II

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