Published Online
on December 19, 2005

A more recent version of this article appeared on March 1, 2006

This Article Full Text (PDF) All Versions of this Article: 47/3/609    most recent 01.HYP.0000197390.10412.c4v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, Y. Articles by Wang, D. H. Search for Related Content PubMed PubMed Citation Articles by Wang, Y. Articles by Wang, D. H. Related Collections Other etiology

Submitted on October 3, 2005
Revised on October 23, 2005

A Novel Mechanism Contributing to Development of Dahl Salt-Sensitive Hypertension. Role of the Transient Receptor Potential Vanilloid Type 1

Youping Wang and Donna H. Wang^*

From the Department of Medicine, Michigan State University, East Lansing.

^* To whom correspondence should be addressed. E-mail: donna.wang{at}ht.msu.edu.

Abstract--To determine the role of the transient receptor potential vanilloid type 1 (TRPV1) channels in development of hypertension in Dahl salt-sensitive (DS) rats fed a high-salt diet (HS), male DS and Dahl salt-resistant (DR) rats were maintained on a low-salt diet (LS) or HS for 3 weeks. HS significantly increased systolic blood pressure in DS+HS rats compared with DS+LS, DR+HS, and DR+LS rats. Intravenous bolus injection of capsazepine (3 mg/kg), a selective TRPV1 antagonist, significantly increased mean arterial pressure in conscious DR+HS rats compared with DR+LS, DS±HS, and DS±LS rats. In contrast, capsaicin (10 or 30 µg/kg), a selective TRPV1 agonist, dose-dependently decreased mean arterial pressure in all of the groups with the most profound magnitude in DR+HS rats compared with the other 3 groups. TRPV1 expression in mesenteric resistance arteries and the renal cortex and medulla, calcitonin gene-related peptide levels in dorsal root ganglia, and calcitonin gene-related peptide-positive sensory nerve density in mesenteric resistance arteries were significantly decreased in DS+HS rats compared with DS+LS, DR+HS, and DR+LS rats. Taken together, our data indicate that the TRPV1 receptor is activated and its expression upregulated during HS intake in DR rats, which acts to prevent salt-induced increases in blood pressure. In contrast, TRPV1 expression and function are impaired in DS rats, which renders DS rats sensitive to salt load in terms of blood pressure regulation.

Key words: peptides • rats, Dahl • hypertension, sodium-dependent • blood pressure

This article has been cited by other articles:

				Y. Wang and D. H. Wang Aggravated renal inflammatory responses in TRPV1 gene knockout mice subjected to DOCA-salt hypertension Am J Physiol Renal Physiol, December 1, 2009; 297(6): F1550 - F1559. [Abstract] [Full Text] [PDF]

				C. Xie and D. H. Wang Ablation of Transient Receptor Potential Vanilloid 1 Abolishes Endothelin-Induced Increases in Afferent Renal Nerve Activity: Mechanisms and Functional Significance Hypertension, December 1, 2009; 54(6): 1298 - 1305. [Abstract] [Full Text] [PDF]

				F. Gao, D. Sui, R. M. Garavito, R. M. Worden, and D. H. Wang Salt Intake Augments Hypotensive Effects of Transient Receptor Potential Vanilloid 4: Functional Significance and Implication Hypertension, February 1, 2009; 53(2): 228 - 235. [Abstract] [Full Text] [PDF]

				T. Katsumata, H. Nakakuki, C. Tokunaga, N. Fujii, M. Egi, T.-H. T. Phan, S. Mummalaneni, J. A. DeSimone, and V. Lyall Effect of Maillard Reacted Peptides on Human Salt Taste and the Amiloride-Insensitive Salt Taste Receptor (TRPV1t) Chem Senses, September 1, 2008; 33(7): 665 - 680. [Abstract] [Full Text] [PDF]

				J. Li and D. H. Wang Role of TRPV1 channels in renal haemodynamics and function in Dahl salt-sensitive hypertensive rats Exp Physiol, August 1, 2008; 93(8): 945 - 953. [Abstract] [Full Text] [PDF]

				Y. Wang, D. Babankova, J. Huang, G. M. Swain, and D. H. Wang Deletion of Transient Receptor Potential Vanilloid Type 1 Receptors Exaggerates Renal Damage in Deoxycorticosterone Acetate-Salt Hypertension Hypertension, August 1, 2008; 52(2): 264 - 270. [Abstract] [Full Text] [PDF]

				T. Ditting, R. Veelken, and K. F. Hilgers Transient Receptor Potential Vanilloid Type 1 Receptors in Hypertensive Renal Damage: A Promising Therapeutic Target? Hypertension, August 1, 2008; 52(2): 213 - 214. [Full Text] [PDF]

				C. Xie, J. R. Sachs, and D. H. Wang Interdependent Regulation of Afferent Renal Nerve Activity and Renal Function: Role of Transient Receptor Potential Vanilloid Type 1, Neurokinin 1, and Calcitonin Gene-Related Peptide Receptors J. Pharmacol. Exp. Ther., June 1, 2008; 325(3): 751 - 757. [Abstract] [Full Text] [PDF]

				I. N. Bratz, G. M. Dick, J. D. Tune, J. M. Edwards, Z. P. Neeb, U. D. Dincer, and M. Sturek Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2489 - H2496. [Abstract] [Full Text] [PDF]

				Y. Wang, N. E. Kaminski, and D. H. Wang Endocannabinoid Regulates Blood Pressure via Activation of the Transient Receptor Potential Vanilloid Type 1 in Wistar Rats Fed a High-Salt Diet J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 763 - 769. [Abstract] [Full Text] [PDF]

				B. Nilius, G. Owsianik, T. Voets, and J. A. Peters Transient Receptor Potential Cation Channels in Disease Physiol Rev, January 1, 2007; 87(1): 165 - 217. [Abstract] [Full Text] [PDF]

				Y. Wang, A. F. Chen, and D. H. Wang Enhanced oxidative stress in kidneys of salt-sensitive hypertension: role of sensory nerves Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3136 - H3143. [Abstract] [Full Text] [PDF]

				R. Inoue, L. J. Jensen, J. Shi, H. Morita, M. Nishida, A. Honda, and Y. Ito Transient Receptor Potential Channels in Cardiovascular Function and Disease Circ. Res., July 21, 2006; 99(2): 119 - 131. [Abstract] [Full Text] [PDF]