Published Online
on December 12, 2005

A more recent version of this article appeared on January 1, 2006

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Submitted on October 11, 2005
Revised on October 25, 2005

Novel Integrative Approaches to the Identification of Candidate Genes in Hypertension

Norbert Hubner; Chana Yagil; and Yoram Yagil^*

From the Max-Delbruck-Center for Molecular Medicine (N.H.), Berlin-Buch, Germany; Israel Rat Genome Center and Laboratory for Molecular Medicine (C.Y., Y.Y.), Department of Nephrology and Hypertension, Faculty of Health Sciences, Barzilai Medical Center, Campus of the Ben-Gurion University, Ashkelon, Israel.

^* To whom correspondence should be addressed. E-mail: labmomed{at}bgumail.bgu.ac.il.

Abstract--Hypertension, diabetes, and obesity are common diseases that are genetically expressed as complex traits. The clinical expression of these diseases, which run in families but have no clear pattern of inheritance, has been attributed to the interaction between multiple genes and the environment. Identifying the underlying genes, a crucial step in understanding the molecular pathogenesis of complex diseases, has had limited success so far, stressing the need for novel strategies to move this process forward. Innovative integrative genetic-genomic approaches have been proposed recently for the identification of new high-priority candidate genes. These strategies, which combine expression profiling with genetic linkage in different ways, may represent a breakthrough in the search for the genes involved in complex diseases.

Key words: genes • gene expression • hypertension • genetics

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