Published Online
on January 9, 2006

A more recent version of this article appeared on February 1, 2006

This Article Full Text (PDF) Data Supplement All Versions of this Article: 47/2/216    most recent 01.HYP.0000201234.35551.2ev1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bahous, S. A. Articles by Safar, M. E. Search for Related Content PubMed PubMed Citation Articles by Bahous, S. A. Articles by Safar, M. E. Pubmed/NCBI databases Medline Plus Health Information Kidney Transplantation Organ Donation Related Collections Other hypertension Transplantation Other diagnostic testing Epidemiology Related Article

Submitted on May 5, 2005
Revised on May 26, 2005

Aortic Stiffness, Living Donors, and Renal Transplantation

Sola Aoun Bahous; Antoine Stephan; Jacques Blacher; and Michel E. Safar^*

From the Nephrology and Transplantation Center (S.A.B., A.S.), Rizk Hopsital, Beirut, Lebanon; and Diagnostic Center (J.B., M.E.S.), Hôtel-Dieu, Paris, France.

^* To whom correspondence should be addressed. E-mail: michel.safar{at}htd.ap-hop-paris.fr.

Abstract--In subjects with renal disease, reduced renal function and increased arterial stiffness are significantly associated in cross-sectional studies. The relationship is independent of age, blood pressure (BP), and atherosclerosis. Because both variables are independent predictors of cardiovascular risk, time-dependent relationships between them are important to determine. Aortic pulse wave velocity was measured noninvasively by comparison with healthy volunteers in 101 living kidney donors and their 101 corresponding recipients. Healthy volunteers were divided into 2 groups: one was recipient related through familial links and the other was nonrecipient related. Independently of age, gender, and BP, pulse wave velocity was significantly elevated in donors and recipients by comparison with the 2 groups of healthy volunteers. Pulse wave velocity was significantly higher in the recipient-related than in the nonrecipient-related group. Whereas in healthy volunteers, pulse wave velocity was exclusively related to age, gender, and BP, in donors and recipients, it was rather associated with a cluster of cardiovascular risk factors, including smoking habits and plasma glucose. Major factors related to pulse wave velocity were renal: time since nephrectomy (donation date) in donors, in whom pulse pressure was specifically associated with proteinuria, and renal rejection in recipients. Plasma creatinine doubling secondary to chronic allograft nephropathy was significantly associated with renal rejection and donor pulse wave velocity, independent of age. Our findings strongly suggest consistent interactions (including familial factors) between kidney function and arterial stiffness. Assessment of cause-effect relationships and implication of biochemical and/or genetic factors warrant additional studies.

Key words: transplantation, renal • kidney • arteries • pulse • risk factors

Related Article:

Preface

David R. Harder
Hypertension 2006 47: 497. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				G. Geis and G. C. Brown The Transnational Traffic in Human Body Parts Journal of Contemporary Criminal Justice, August 1, 2008; 24(3): 212 - 224. [Abstract] [PDF]

				F. Verbeke, W. Van Biesen, P. Peeters, L. M. Van Bortel, and R. C. Vanholder Arterial stiffness and wave reflections in renal transplant recipients Nephrol. Dial. Transplant., October 1, 2007; 22(10): 3021 - 3027. [Abstract] [Full Text] [PDF]

				G. Schillaci, M. Pirro, M. R. Mannarino, G. Pucci, G. Savarese, S. S. Franklin, and E. Mannarino Relation Between Renal Function Within the Normal Range and Central and Peripheral Arterial Stiffness in Hypertension Hypertension, October 1, 2006; 48(4): 616 - 621. [Abstract] [Full Text] [PDF]

				E. S. Ommen, J. A. Winston, and B. Murphy Medical Risks in Living Kidney Donors: Absence of Proof Is Not Proof of Absence Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 885 - 895. [Abstract] [Full Text] [PDF]

				R. D. Toto Pressure, Waves, and Kidney Outcomes in Kidney Transplant Donors and Recipients Hypertension, February 1, 2006; 47(2): 141 - 142. [Full Text] [PDF]