Published Online
on March 6, 2006

A more recent version of this article appeared on April 1, 2006

This Article Full Text (PDF) All Versions of this Article: 47/4/650    most recent 01.HYP.0000205224.58715.ccv1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schmidt, B. M.W. Articles by Schmieder, R. E. Search for Related Content PubMed PubMed Citation Articles by Schmidt, B. M.W. Articles by Schmieder, R. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Related Collections Other hypertension Endothelium/vascular type/nitric oxide Related Article

Submitted on August 11, 2005
Revised on August 31, 2005

Rapid Nongenomic Effects of Aldosterone on the Renal Vasculature in Humans

Bernhard M.W. Schmidt; Ulla Sammer; Ingrid Fleischmann; Markus Schlaich; Christian Delles; and Roland E. Schmieder^*

From the Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, Germany.

^* To whom correspondence should be addressed. E-mail: roland.schmieder{at}rzmail.uni-erlangen.de.

Abstract--There is increasing evidence for the importance of rapid nongenomic effects of aldosterone on the human vasculature. In vitro animal experiments in renal arterioles also suggest the presence of such effects on the renal vasculature. We conducted a clinical study to explore these effects in vivo in humans. Thirteen healthy male volunteers were examined. Aldosterone (500 µg) or placebo was injected intravenously with or without coinfusion of N(G) monomethyl-L-arginine (L-NMMA) in a randomized, double-blinded 4-fold crossover design. Renal plasma flow and glomerular filtration rate were measured by constant infusion clearance technique using inulin and para-aminohippuric acid. Injection of aldosterone without concomitant infusion of L-NMMA changed the renal plasma flow and glomerular filtration rate, not statistically significant compared with placebo. Coinfusion of L-NMMA unmasked the effect of aldosterone: aldosterone with L-NMMA decreased the glomerular filtration rate slightly (-1.4±6.2 mL/min), whereas infusion of L-NMMA alone increased the glomerular filtration rate (8.3±9.8 mL/min; P=0.004). L-NMMA alone decreased renal plasma flow by 58.2±97.5 mL/min, and aldosterone with L-NMMA decreased renal plasma flow by 190.0±213.7 mL/min (P=0.074). Accordingly, Aldosterone with L-NMMA increased renal vascular resistance much more than L-NMMA alone (1588±237 versus 614±240 dynxsxcm^-5; P=0.014). These data indicate that aldosterone acts via rapid nongenomic effects in vivo in humans at the renal vasculature. Antagonizing the endothelial NO synthase unmasks these effects. Therefore, rapid nongenomic aldosterone effects increase renal vascular resistance and thereby mediate arterial hypertension if endothelial dysfunction is present.

Key words: aldosterone • nitric oxide • glomerular filtration rate

Related Article:

Nongenomic Renal Effects of Aldosterone: Dependency on NO and Genomic Actions

Tae-Yon Chun and J. Howard Pratt
Hypertension 2006 47: 636-637. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				K. J. Schjoedt, P. K. Christensen, A. Jorsal, F. Boomsma, P. Rossing, and H.-H. Parving Autoregulation of glomerular filtration rate during spironolactone treatment in hypertensive patients with type 1 diabetes: a randomized crossover trial Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3343 - 3349. [Abstract] [Full Text] [PDF]

				M. Cortinovis, N. Perico, D. Cattaneo, and G. Remuzzi Aldosterone and progression of kidney disease Therapeutic Advances in Cardiovascular Disease, April 1, 2009; 3(2): 133 - 143. [Abstract] [PDF]

				T.-Y. Chun, L. Bankir, G. J. Eckert, D. G. Bichet, C. Saha, S.-A. Zaidi, M. A. Wagner, and J. H. Pratt Ethnic Differences in Renal Responses to Furosemide Hypertension, August 1, 2008; 52(2): 241 - 248. [Abstract] [Full Text] [PDF]

				F. Nietlispach, B. Julius, R. Schindler, A. Bernheim, C. Binkert, W. Kiowski, and H. P. Brunner-La Rocca Influence of Acute and Chronic Mineralocorticoid Excess on Endothelial Function in Healthy Men Hypertension, July 1, 2007; 50(1): 82 - 88. [Abstract] [Full Text] [PDF]

				D. W. Good Nongenomic Actions of Aldosterone on the Renal Tubule Hypertension, April 1, 2007; 49(4): 728 - 739. [Full Text] [PDF]

				T.-Y. Chun and J. H. Pratt Nongenomic Renal Effects of Aldosterone: Dependency on NO and Genomic Actions Hypertension, April 1, 2006; 47(4): 636 - 637. [Full Text] [PDF]