Published Online
on February 20, 2006

A more recent version of this article appeared on April 1, 2006

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Submitted on December 14, 2005
Revised on January 1, 2006

Endothelium-Derived Epoxyeicosatrienoic Acids and Vascular Function

Ingrid Fleming^* and Rudi Busse

From the Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

^* To whom correspondence should be addressed. E-mail: fleming{at}em.uni-frankfurt.de.

Abstract--Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial cells is an important step in the NO and prostacyclin-independent vasodilatation of several vascular beds, and EETs have been identified as an endothelium-derived hyperpolarizing factor. However, EETs also exert membrane potential-independent effects and modulate several signaling cascades that affect endothelial cell proliferation and angiogenesis. This review summarizes the role of CYP-derived EETs in endothelium-derived hyperpolarizing factor-mediated responses and highlights the evidence indicating that EETs are important second messengers involved in endothelial cell signaling pathways related to angiogenesis.

Key words: calcium channels • endothelium-derived factors • hypertension • vasodilatation

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