Published Online
on March 6, 2006

A more recent version of this article appeared on May 1, 2006

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Submitted on December 23, 2005
Revised on January 3, 2006

A Place in Our Hearts for the Lowly Angiotensin 1-7 Peptide?

Timothy L. Reudelhuber^*

From the Laboratory of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada.

^* To whom correspondence should be addressed. E-mail: reudelt{at}ircm.qc.ca.

Abstract--In addition to its role in modulating blood pressure and fluid volume, the activity of the renin-angiotensin system has been implicated in numerous other functions, including memory, kidney development, and the function of the heart and lungs. The latest breakthroughs in this area have focused on a recently discovered member of the renin-angiotensin system, the enzyme angiotensin-converting enzyme 2, and on the peptide product of its action on angiotensin II, angiotensin 1-7. This review will highlight recent advances made in understanding the biochemistry and physiology of angiotensin-converting enzyme 2 and angiotensin 1-7 and their potential roles in cardiovascular pathophysiology.

Key words: renin-angiotensin system • angiotensin-converting enzyme • angiotensin

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