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Published Online
on February 26, 2007

Hypertension. 2007
Published online before print February 26, 2007, doi: 10.1161/01.HYP.0000260092.93964.ed
A more recent version of this article appeared on April 1, 2007
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Submitted on November 27, 2006
Revised on December 14, 2006

Genome-Wide Scan for Blood Pressure in Australian and Dutch Subjects Suggests Linkage at 5P, 14Q, and 17P

Jouke-Jan Hottenga; John B. Whitfield; Danielle Posthuma; Gonneke Willemsen; Eco J.C. de Geus; Nicholas G. Martin; and Dorret I. Boomsma

From the Department of Biological Psychology and the Center for Neurogenomics and Clinical Research (J.-J.H., D.P., G.W., E.J.C.d.G., D.I.B.), Vrije Universiteit, Amsterdam, The Netherlands; and the Genetic Epidemiology Laboratory (J.B.W., N.G.M.), Queensland Institute of Medical Research, Brisbane, Australia.

Abstract--Large-scale studies estimate the heritability of blood pressure at {approx}50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation.
Key words: epidemiology • twin study • blood pressure • genetic linkage • longitudinal studies • candidate genes




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P.-a. B. Shih and D. T. O'Connor
Hereditary Determinants of Human Hypertension: Strategies in the Setting of Genetic Complexity
Hypertension, June 1, 2008; 51(6): 1456 - 1464.
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