Hypertension, Vol 13, 3-8, Copyright © 1989 by American Heart Association
TD Berry, SJ Hasstedt, SC Hunt, LL Wu, JB Smith, KO Ash, H Kuida and RR Williams
The inheritance of 12-hour overnight total urinary kallikrein excretion and
its association with family history of essential hypertension were studied
in 405 normotensive adults and 391 youths in 57 Utah pedigrees. Total
urinary kallikrein excretion was highly familial with 51% of the total
variance attributable to a dominant allele for high total urinary
kallikrein excretion and 27% attributable to the combined effects of
polygenes and shared family environment. An estimated 28% of the population
has one or two copies of the dominant allele for high total urinary
kallikrein excretion (2.3 SD units higher than the low homozygotes). About
83% of the population could be assigned to one of the two genotypic
populations. Individuals with the high total urinary kallikrein excretion
genotype were significantly less likely to have one or two hypertensive
parents (relative odds = 0.56, p = 0.042). We conclude that a dominant
allele expressed as high total urinary kallikrein excretion may be
associated with decreased risk of essential hypertension. Further studies
should be performed to confirm this finding and to test for interactions
between this apparently protective gene and other genetic and environmental
determinants of essential hypertension.
ARTICLES
A gene for high urinary kallikrein may protect against hypertension in Utah kindreds
Department of Medicine, University of Utah Medical School, Salt Lake City.
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