Hypertension, Vol 14, 28-35, Copyright © 1989 by American Heart Association
JS Floras, CA Sinkey, PE Aylward, DR Seals, PN Thoren and AL Mark
To determine if there would be a decrease in blood pressure after exercise
in patients with borderline hypertension and if this decrease would be
accompanied by a decrease in sympathetic nerve activity to muscle, we
recorded multifiber postganglionic muscle sympathetic activity from the
peroneal nerve at rest in nine men with borderline hypertension (age 25 +/-
1 years, mean +/- SEM) before and 60 minutes after 45 minutes of submaximal
treadmill exercise. In addition, responses to a cold pressor test,
handgrip, and the Valsalva maneuver were recorded before and after
exercise. Four subjects were also studied before and after "sham" exercise.
Sham exercise had no effect on blood pressure or sympathetic nerve activity
whereas resting systolic blood pressure was lower after treadmill exercise
in seven subjects (from 136 +/- 4 before to 123 +/- 2 mm Hg 60 minutes
after exercise; p less than 0.01). Sixty minutes after exercise,
sympathetic nerve activity was lower in all seven subjects (from 19 +/- 2
to 11 +/- 2 bursts/min, p less than 0.015; or from 27 +/- 3 to 14 +/- 2
bursts/100 heartbeats, p less than 0.005) but was slightly increased in the
two subjects without postexercise hypotension. Heart rate and pressor and
sympathoneural responses to the cold pressor test, handgrip, and the
Valsalva maneuver were not altered by prior exercise. When nitroprusside
was infused in five subjects to produce a reduction in systolic blood
pressure similar to that seen 60 minutes after exercise, this drug
increased sympathetic discharge from 37 +/- 6 to 57 +/- 4 bursts/100
heartbeats (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Postexercise hypotension and sympathoinhibition in borderline hypertensive men
Department of Medicine, University of Iowa College of Medicine, Iowa City.
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