Hypertension, Vol 15, 274-283, Copyright © 1990 by American Heart Association
S Sasaki and RA Dampney
The rostral and caudal parts of the ventrolateral medulla play a major role
in the control of blood pressure. Both regions contain a high density of
receptor binding sites for angiotensin II, and it has been shown previously
that microinjection of angiotensin II into the rostral ventrolateral
medulla causes a rise in blood pressure. The aims of this study were to
determine the cardiovascular effects of microinjection of angiotensin II
and its specific antagonist [Sar1Thr8]angiotensin II into the caudal
ventrolateral medulla and to characterize the regional vascular effects
elicited by both compounds in the rostral ventrolateral medulla.
Microinjections of angiotensin II (0.2-20 pmol) into histologically
verified sites in the caudal ventrolateral medulla of anesthetized
baroreceptor-denervated rabbits produced dose-dependent decreases in blood
pressure and renal sympathetic nerve activity, whereas microinjection of
[Sar1Thr8]angiotensin II (40 pmol) produced increases in these variables.
In the rostral ventrolateral medulla, angiotensin II (0.02-20 pmol)
elicited a dose-dependent increase in blood pressure, iliac vascular
resistance, and renal sympathetic nerve activity, whereas
[Sar1Thr8]angiotensin II (40 pmol) produced decreases in these variables.
The effects on heart rate elicited by either compound in the rostral or
caudal ventrolateral medulla were small but were in the same direction as
the other cardiovascular variables. In contrast, angiotensin II had no
detectable effect on sympathoexcitatory neurons within the rostral
dorsomedial medulla, a region that lacks angiotensin II receptor binding
sites. The results indicate that endogenous angiotensin II acts on specific
receptors within the rostral and caudal parts of the ventrolateral medulla
and has a tonic excitatory action on sympathoexcitatory and
sympathoinhibitory neurons within these respective regions.
ARTICLES
Tonic cardiovascular effects of angiotensin II in the ventrolateral medulla
Department of Physiology, University of Sydney, Australia.
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