Hypertension, Vol 15, 451-458, Copyright © 1990 by American Heart Association
MG Cogan
Angiotensin II has recently been shown to exert potent control over sodium
and water absorption in the proximal convoluted tubule. This transport
stimulation is effected by receptors on both the luminal and basolateral
membranes of cells located predominantly in the early, S1 proximal tubule.
Angiotensin II increases transport primarily by a Gi protein-mediated
reduction in intracellular cyclic adenosine monophosphate, which enhances
the affinity of the Na(+)-H+ antiporter. Change in early proximal
acidification ultimately causes alteration in the amount of sodium chloride
leaving the proximal tubule and entering the urine. These direct tubular
transport actions by angiotensin II may participate importantly in various
physiological actions of the kidney, including the renal response to change
in dietary sodium intake and in extracellular volume, as well as in
pathophysiological processes such as hypertension.
ARTICLES
Angiotensin II: a powerful controller of sodium transport in the early proximal tubule
Division of Nephrology, University of California, San Francisco.
This article has been cited by other articles:
 |
|
 |
|
  A. Chagnac, M. Herman, B. Zingerman, A. Erman, B. Rozen-Zvi, J. Hirsh, and U. Gafter Obesity-induced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption Nephrol. Dial. Transplant., December 1, 2008; 23(12): 3946 - 3952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dagan, J. Gattineni, V. Cook, and M. Baum Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1230 - R1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. W. Tang, A. C. Parameswaran, A. P. Maroo, and G. S. Francis Aldosterone Receptor Antagonists in the Medical Management of Chronic Heart Failure Mayo Clin. Proc., December 1, 2005; 80(12): 1623 - 1630. [Abstract] [PDF]
|
|
|
|
 |
|
 H. A. Kadi, H. Nasrat, and F. B. Pipkin A prospective, longitudinal study of the renin-angiotensin system, prostacyclin and thromboxane in the first trimester of normal human pregnancy: association with birthweight Hum. Reprod., November 1, 2005; 20(11): 3157 - 3162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Banday, A. H. Siddiqui, M. M. Menezes, and T. Hussain Insulin treatment enhances AT1 receptor function in OK cells Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1213 - F1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Raj, I. Biaggioni, P. C. Yamhure, B. K. Black, S. Y. Paranjape, D. W. Byrne, and D. Robertson Renin-Aldosterone Paradox and Perturbed Blood Volume Regulation Underlying Postural Tachycardia Syndrome Circulation, April 5, 2005; 111(13): 1574 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gonzalez-Villalobos, R. B. Klassen, P. L. Allen, L. G. Navar, and T. G. Hammond Megalin binds and internalizes angiotensin II Am J Physiol Renal Physiol, February 1, 2005; 288(2): F420 - F427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Slomowitz, F. B. Gabbai, S. J. Khang, J. Satriano, S. Thareau, A. Deng, S. C. Thomson, R. C. Blantz, and K. A. Munger Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expression Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1184 - R1189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lerolle, S. Bourgeois, F. Leviel, G. Lebrun, M. Paillard, and P. Houillier Angiotensin II inhibits NaCl absorption in the rat medullary thick ascending limb Am J Physiol Renal Physiol, September 1, 2004; 287(3): F404 - F410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Le, M. I. Oliverio, H.-S. Kim, H. Salzler, R. C. Dash, D. N. Howell, O. Smithies, S. Bronson, and T. M. Coffman A {gamma}GT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice Physiol Genomics, August 11, 2004; 18(3): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Lavoie, K. D. Lake-Bruse, and C. D. Sigmund Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule Am J Physiol Renal Physiol, May 1, 2004; 286(5): F965 - F971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.Y. Man, J. Clulow, and R.C. Jones Signal Transduction in the Ductuli Efferentes Testis of the Rat: Inhibition of Fluid Reabsorption by Cyclic Adenosine 3', 5'-Monophosphate Biol Reprod, November 1, 2003; 69(5): 1714 - 1718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Lavoie and C. D. Sigmund Minireview: Overview of the Renin-Angiotensin System--An Endocrine and Paracrine System Endocrinology, June 1, 2003; 144(6): 2179 - 2183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, L. D. Asico, X. Wang, U. Hopfer, G. M. Eisner, R. A. Felder, and P. A. Jose Angiotensin II Regulation of AT1 and D3 Dopamine Receptors in Renal Proximal Tubule Cells of SHR Hypertension, March 1, 2003; 41(3): 724 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-F. LIN, S.-H. LIN, W.-S. TSAI, M.R. DAVIDS, and M.L. HALPERIN Severe hypokalaemia in a Chinese male QJM, October 1, 2002; 95(10): 695 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Marenzi, G. Lauri, E. Assanelli, M. Grazi, J. Campodonico, G. Famoso, and P. Agostoni Serum to urinary sodium concentration ratio is an estimate of plasma renin activity in congestive heart failure Eur J Heart Fail, October 1, 2002; 4(5): 597 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Frindt, T. McNair, A. Dahlmann, E. Jacobs-Palmer, and L. G. Palmer Epithelial Na channels and short-term renal response to salt deprivation Am J Physiol Renal Physiol, October 1, 2002; 283(4): F717 - F726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Quan and M. Baum The renal nerve is required for regulation of proximal tubule transport by intraluminally produced ANG II Am J Physiol Renal Physiol, March 1, 2001; 280(3): F524 - F529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M Coffman, L. P Audoly, and M. I Oliverio Review: Gene targeting studies of angiotensin II type 1 (AT1) receptors Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S10 - S15. [PDF]
|
|
|
|
|
|
J. Bauersachs, D. Fraccarollo, G. Ertl, N. Gretz, M. Wehling, and M. Christ Striking Increase of Natriuresis by Low-Dose Spironolactone in Congestive Heart Failure Only in Combination With ACE Inhibition : Mechanistic Evidence to Support RALES Circulation, November 7, 2000; 102(19): 2325 - 2328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A Carroll and J. C McGiff A new class of lipid mediators: cytochrome P450 arachidonate metabolites Thorax, October 1, 2000; 55(90002): 13S - 16. [Full Text]
|
|
|
|
 |
|
 L. CERVENKA, K. D. MITCHELL, and L. G. NAVAR Renal Function in Mice: Effects of Volume Expansion and AngiotensinII J. Am. Soc. Nephrol., December 1, 1999; 10(12): 2631 - 2636. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. McGiff and J. Quilley 20-HETE and the kidney: resolution of old problems and new beginnings Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R607 - R623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Imig, G. L. Navar, L.-X. Zou, K. C. O'Reilly, P. L. Allen, J. H. Kaysen, T. G. Hammond, and L. G. Navar Renal endosomes contain angiotensin peptides, converting enzyme, and AT1A receptors Am J Physiol Renal Physiol, August 1, 1999; 277(2): F303 - F311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Gadano, R Moreau, J Heller, C Chagneau, F Vachiery, C Trombino, A Elman, C Denie, D Valla, and D Lebrec Relation between severity of liver disease and renal oxygen consumption in patients with cirrhosis Gut, July 1, 1999; 45(1): 117 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ingelfinger, F. Jung, D. Diamant, L. Haveran, E. Lee, A. Brem, and S.-S. Tang Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback Am J Physiol Renal Physiol, February 1, 1999; 276(2): F218 - F227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cervenka, C.-T. Wang, K. D. Mitchell, and L. G. Navar Proximal Tubular Angiotensin II Levels and Renal Functional Responses to AT1 Receptor Blockade in Nonclipped Kidneys of Goldblatt Hypertensive Rats Hypertension, January 1, 1999; 33(1): 102 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hussain, R. Abdul-Wahab, D. K. Kotak, and M. F. Lokhandwala Bromocriptine Regulates Angiotensin II Response on Sodium Pump in Proximal Tubules Hypertension, December 1, 1998; 32(6): 1054 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Thekkumkara, R. Cookson, and S. L. Linas Angiotensin (AT1A) receptor-mediated increases in transcellular sodium transport in proximal tubule cells Am J Physiol Renal Physiol, May 1, 1998; 274(5): F897 - F905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cervenka, C.-T. Wang, and L. G. Navar Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats Am J Physiol Renal Physiol, May 1, 1998; 274(5): F940 - F945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Jacob, A. C. Ertl, J. R. Shannon, R. Furlan, R. M. Robertson, and D. Robertson Effect of standing on neurohumoral responses and plasma volume in healthy subjects J Appl Physiol, March 1, 1998; 84(3): 914 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-F. Cheng, J.-L. Wang, G. P. Vinson, and R. C. Harris Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule Am J Physiol Renal Physiol, January 1, 1998; 274(1): F10 - F17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ichihara, E. W. Inscho, J. D. Imig, R. E. Michel, and L. G. Navar Role of Renal Nerves in Afferent Arteriolar Reactivity in Angiotensin-Induced Hypertension Hypertension, January 1, 1997; 29(1): 442 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Harrison-Bernard, J. Zhuo, H. Kobori, M. Ohishi, and L. G. Navar Intrarenal AT1 receptor and ACE binding in ANG II-induced hypertensive rats Am J Physiol Renal Physiol, January 1, 2002; 282(1): F19 - F25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cheema-Dhadli, S.-H. Lin, and M. L. Halperin Mechanisms used to dispose of progressively increasing alkali load in rats Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1049 - F1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Quan and M. Baum Renal nerve stimulation augments effect of intraluminal angiotensin II on proximal tubule transport Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1043 - F1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. DAVISSON, Y. DING, D. E. STEC, J. F. CATTERALL, and C. D. SIGMUND Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice Physiol Genomics, July 15, 1999; 1(1): 3 - 9. [Abstract] [Full Text] [PDF]
|
|