Hypertension, Vol 17, 669-677, Copyright © 1991 by American Heart Association
RJ Troisi, ST Weiss, DR Parker, D Sparrow, JB Young and L Landsberg
The hypothesis that dietary intake and obesity stimulate the sympathetic
nervous system was investigated in a cross-sectional study of 572 men aged
43-85 years from the Normative Aging Study. Habitus was represented by body
mass index, as a measure of overall adiposity, and by the ratio of
abdomen-to-hip circumference (abdomen/hip ratio), as a measure of
centripetal fat distribution. Sympathetic activity was assessed by
measurement of 24-hour urinary norepinephrine excretion. Increased body
mass index and total caloric intake were independently associated with
increased 24-hour urinary norepinephrine excretion (p = 0.0001 and p =
0.0055, respectively). In addition, mean urinary norepinephrine excretion
was higher in subjects classified as either hyperglycemic (serum fasting
glucose greater than or equal to 113 mg/dl) and hyperinsulinemic (serum
fasting insulin greater than or equal to 19 microIU/ml) (p = 0.0023) or in
subjects classified as either hyperglycemic or hyperinsulinemic (p =
0.0063) than the mean urinary norepinephrine excretion in normal subjects.
These relations were demonstrated to be independent of age, smoking status,
and physical activity. Our results are consistent with the hypothesis that
insulin mediates sympathetic stimulation in response to dietary intake and
increases sympathetic nervous system activity in the obese.
ARTICLES
Relation of obesity and diet to sympathetic nervous system activity
Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Mass.
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