This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yang, R. H. Articles by Oparil, S. Search for Related Content PubMed PubMed Citation Articles by Yang, R. H. Articles by Oparil, S.

Hypertension, Vol 19, 198-205, Copyright © 1992 by American Heart Association

ARTICLES

Pressor effect of blocking atrial natriuretic peptide in nucleus tractus solitarii

RH Yang, HK Jin, JM Wyss, YF Chen and S Oparil
Department of Medicine, University of Alabama, Birmingham.

Previous studies have shown that microinjection of atrial natriuretic peptide into the caudal nucleus tractus solitarii produces significant increases in local neuronal firing rate associated with reductions in arterial pressure in anesthetized Wistar rats. Single units excited by microinjection of atrial natriuretic peptide into the caudal nucleus tractus solitarii were also excited by activation of arterial baroreceptors and inhibited by baroreceptor unloading. To test the hypothesis that endogenous atrial natriuretic peptide in caudal nucleus tractus solitarii is involved in the tonic control of blood pressure in the rat, we administered a blocking monoclonal antibody to atrial natriuretic peptide in a volume of 50 nl artificial cerebrospinal fluid via microinjection into the caudal nucleus tractus solitarii of spontaneously hypertensive and Wistar-Kyoto rats and observed the effects on mean arterial pressure and heart rate. Control injections of monoclonal antibody were administered into the rostral nucleus tractus solitarii, hypoglossal nucleus, spinal trigeminal nucleus, and cuneate nucleus of spontaneously hypertensive rats. Microinjection of monoclonal antibody into the caudal nucleus tractus solitarii caused significant increases in mean arterial pressure in spontaneously hypertensive rats but not in Wistar-Kyoto rats. There was no concomitant change in heart rate. Control injections of purified mouse immunoglobulin into the caudal nucleus tractus solitarii and of monoclonal antibody into the control neuronal groups listed above had no effect on mean arterial pressure. These results suggest that endogenous atrial natriuretic peptide in the caudal nucleus tractus solitarii mediates tonic control of blood pressure in spontaneously hypertensive rats but not in normotensive Wistar-Kyoto rats.

This article has been cited by other articles:

				K. R. Johnson and K. R. Olson The response of non-traditional natriuretic peptide production sites to salt and water manipulations in the rainbow trout J. Exp. Biol., September 15, 2009; 212(18): 2991 - 2997. [Abstract] [Full Text] [PDF]

				L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF]

				S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, T. Ishikawa, S. Ichikawa, T. Suzuki, and M. Kurabayashi Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity in Patients with Decompensated Congestive Heart Failure J. Nucl. Med., July 1, 2004; 45(7): 1108 - 1113. [Abstract] [Full Text] [PDF]

				N. Peng, B. D. Chambless, S. Oparil, and J. M. Wyss {alpha}2A-Adrenergic Receptors Mediate Sympathoinhibitory Responses to Atrial Natriuretic Peptide in the Mouse Anterior Hypothalamic Nucleus Hypertension, March 1, 2003; 41(3): 571 - 575. [Abstract] [Full Text] [PDF]

				U. Elkayam, M. W. Akhter, P. Tummala, S. Khan, and H. Singh Nesiritide: A New Drug for the Treatment of Decompensated Heart Failure Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2002; 7(3): 181 - 194. [Abstract] [PDF]

				P.R Kalra, S.D Anker, A.D Struthers, and A.J.S Coats The role of C-type natriuretic peptide in cardiovascular medicine Eur. Heart J., June 2, 2001; 22(12): 997 - 1007. [PDF]

				J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]

				B. L. Abramson, S.-i. Ando, C. F. Notarius, G. A. Rongen, and J. S. Floras Effect of Atrial Natriuretic Peptide on Muscle Sympathetic Activity and Its Reflex Control in Human Heart Failure Circulation, April 13, 1999; 99(14): 1810 - 1815. [Abstract] [Full Text] [PDF]

				E. R. Levin, D. G. Gardner, and W. K. Samson Natriuretic Peptides N. Engl. J. Med., July 30, 1998; 339(5): 321 - 328. [Full Text] [PDF]

				R. A. Johnson, E. Colombari, D. S. A. Colombari, M. Lavesa, W. T. Talman, and A. Nasjletti Role of Endogenous Carbon Monoxide in Central Regulation of Arterial Pressure Hypertension, October 1, 1997; 30(4): 962 - 967. [Abstract] [Full Text]

				S.-T. Zhu, Y.-F. Chen, J. M. Wyss, K. Nakao, H. Imura, S. Oparil, and D. A. Calhoun Atrial Natriuretic Peptide Blunts Arterial Baroreflex in Spontaneously Hypertensive Rats Hypertension, February 1, 1996; 27(2): 297 - 302. [Abstract] [Full Text]