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Hypertension, Vol 2, 125-129, Copyright © 1980 by American Heart Association

ARTICLES

Hypertension produced by sodium depletion and unilateral nephrectomy: a new experimental model

AA Seymour, JO Davis, RH Freeman, JM DeForrest, BP Rowe, GA Stephens and GM Williams

Unilateral nephrectomy of sodium-restricted male Sprague-Dawley rats produced a sustained elevation in systolic blood pressure (SBP) that was reversed by sodium repletion. A chronic intraperitoneal infuson of SQ14,225 prevented the development of hypertension in sodium-deplete unilaterally nephrectomized rats. Sodium depletion of two-kidney rats increased SBP to a lesser extent, while unilateral nephrectomy of sodium replete animals had no effect. These results provide evidence for a new model of experimental hypertension in the rat and emphasize the importance of a renal component, as demonstrated by unilateral nephrectomy, in the maintenance of normal pressure-volume relationships.