This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thurston, H. Articles by Swales, J. D. Search for Related Content PubMed PubMed Citation Articles by Thurston, H. Articles by Swales, J. D.

Hypertension, Vol 2, 256-265, Copyright © 1980 by American Heart Association

ARTICLES

Reversal of two-kidney one clip renovascular hypertension in the rat

H Thurston, RF Bing and JD Swales

Attempted correction of two-kidney, one clip Goldblatt hypertension in the rat was carried out by three techniques; removal of the constricting clip, removal of the ischemic kidney, and converting enzyme blockade by oral captopril. Since duration of hypertension is said to be a critical factor, groups of rats were studied after short term (less than 6 weeks from clipping) and chronic (greater than 4 months) hypertension. Blood pressure, sodium balance, and plasma renin concentration (PRC) were followed before and after these correcting procedures. In a control group of animals, removal of a loose renal artery clip did not influence blood pressure and only caused trivial postoperative retention of sodium. Unclipping, however, normalized blood pressure in both short-term and chronic hypertension. After a major postoperative fall, blood pressure returned to somewhat elevated levels after nephrectomy in animals with chronic (but not short-term) hypertension. Sodium balance became markedly positive with the fall in blood pressure of operated hypertensive animals and was significantly correlated with the fall in blood pressure of operated hypertensive animals and was significantly correlated with the fall in blood pressure in these four groups at 7 days (r = 0.43). Captopril also produced a fall in blood pressure at 24 hours, with a positive sodium balance, although the relationship between blood pressure fall and sodium balance did not reach statistical significance (r = 0.30). The PRC was elevated in all hypertensive groups, although individual values overlapped with values from normal rats and nonhypertensive rats with a loose renal artery clip. The PRC fell to normal or subnormal values after either operative procedure and stabilized for at least 2 months independently of whether blood pressure fell or not. It is concluded that neither sodium retention nor renin hypersecretion maintains blood pressure in this model. Also, the rapidity of the blood pressure fall is not consistent with a role for vascular hypertrophy. The greater efficacy of unclipping suggests that the revascularized kidney after this procedure exerts a vasodepressor function independent of sodium excretion or the renin-angiotensin system.

This article has been cited by other articles:

				M. J. Rieder, R. J. Roman, and A. S. Greene Reversal of Microvascular Rarefaction and Reduced Renal Mass Hypertension Hypertension, July 1, 1997; 30(1): 120 - 127. [Abstract] [Full Text]

				W. H. Beierwaltes, D'A. L. Potter, O. A. Carretero, and D. H. Sigmon Nitric Oxide Synthesis Inhibition Blocks Reversal of Two-Kidney, One Clip Renovascular Hypertension After Unclipping Hypertension, February 1, 1995; 25(2): 174 - 179. [Abstract] [Full Text]

				C. K. Kost Jr, P. Li, and E. K. Jackson Blood Pressure After Captopril Withdrawal From Spontaneously Hypertensive Rats Hypertension, January 1, 1995; 25(1): 82 - 87. [Abstract] [Full Text]