This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by DiBona, G. F. Articles by Jones, S. Y. Search for Related Content PubMed PubMed Citation Articles by DiBona, G. F. Articles by Jones, S. Y.

Hypertension, Vol 21, 222-226, Copyright © 1993 by American Heart Association

ARTICLES

Cardiac volume receptor reflex in borderline hypertensive rats

GF DiBona and SY Jones
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.

With increased dietary NaCl intake (8% NaCl), borderline hypertensive rats (BHR) develop hypertension and exhibit an exaggerated natriuresis in response to intravenous isotonic saline volume expansion. The exaggerated natriuresis is mediated by the concurrent exaggerated withdrawal of efferent renal sympathetic nerve activity since prior renal denervation eliminates the exaggerated natriuretic response. It was the objective of the present study to examine cardiac volume receptor reflex control of efferent renal sympathetic nerve activity in BHR made hypertensive by increased dietary NaCl intake. BHR were fed either 1% or 8% NaCl from age 4 to 16 weeks. BHR fed 8% NaCl were hypertensive (148 +/- 9 mmHg) compared with BHR fed 1% NaCl (115 +/- 6 mm Hg, p < 0.05). In one protocol, measurements of right atrial pressure and efferent renal sympathetic nerve activity were made in sinoaortic-denervated BHR before and during a 10% body weight intravenous isotonic saline volume load. Compared with 1% NaCl BHR, 8% NaCl BHR showed both a greater maximal inhibition of efferent renal sympathetic nerve activity (-67 +/- 4% versus -31 +/- 3% of control, p < 0.05) and gain (-22.0 +/- 2.3 versus -9.7 +/- 1.7%/mm Hg, p < 0.05). In a second protocol, measurements of efferent renal sympathetic nerve activity were made in sinoaortic-denervated BHR before and during graded frequency stimulation of the central portion of the sectioned vagus nerve.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				G. F. DiBona and S. Y. Jones Dynamic Analysis of Renal Nerve Activity Responses to Baroreceptor Denervation in Hypertensive Rats Hypertension, April 1, 2001; 37(4): 1153 - 1163. [Abstract] [Full Text] [PDF]

				T. Hines Baroreceptor afferent discharge in the pregnant rat Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1433 - R1440. [Abstract] [Full Text] [PDF]

				G. F. DiBona, S. Y. Jones, and U. C. Kopp Renal Mechanoreceptor Dysfunction : An Intermediate Phenotype in Spontaneously Hypertensive Rats Hypertension, January 1, 1999; 33(1): 472 - 475. [Abstract] [Full Text] [PDF]

				O. Grisk and G. F. DiBona Cardiopulmonary Baroreflex in NaCl-Induced Hypertension in Borderline Hypertensive Rats Hypertension, January 1, 1997; 29(1): 464 - 470. [Abstract] [Full Text] [PDF]

				G. F. DiBona, S. Y. Jones, and L. L. Sawin Renal Sympathetic Neural Mechanisms as Intermediate Phenotype in Spontaneously Hypertensive Rats Hypertension, March 1, 1996; 27(3): 626 - 630. [Abstract] [Full Text]

				G. F. DiBona and S. Y. Jones Analysis of Renal Sympathetic Nerve Responses to Stress Hypertension, April 1, 1995; 25(4): 531 - 538. [Abstract] [Full Text]