Hypertension, Vol 21, 294-300, Copyright © 1993 by American Heart Association
R Lariviere, G Thibault and EL Schiffrin
Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide produced in the
endothelium of blood vessels that may play an important role in the control
of local blood flow and could be involved in the pathogenesis of
hypertension. We investigated immunoreactive ET-1 (ir-ET-1) levels in acid
extracts from blood vessels of deoxycorticosterone acetate (DOCA)-salt and
spontaneously hypertensive rats. We found that segments of thoracic aorta
and the mesenteric vascular bed contain significantly more ir-ET-1 (11.84
+/- 0.84 and 17.30 +/- 1.89 fmol, respectively) than uninephrectomized
control rats (1.78 +/- 0.20 and 9.19 +/- 0.63 fmol, respectively; p <
0.001). High performance liquid chromatography showed that ir-ET-1 of blood
vessels of DOCA-salt hypertensive rats eluted in the same position as
synthetic ET-1. Significantly increased ir-ET-1 was localized by
immunohistochemistry in endothelial cells of aorta and large and small
mesenteric arteries of DOCA-salt hypertensive rats. In contrast to the
latter, in spontaneously hypertensive rats, vascular content of ir-ET-1 was
similar to that of blood vessels of Wistar-Kyoto control rats, at both 6
and 16 weeks of age. High levels of vascular ET-1 may explain the
downregulation of vascular endothelin receptors previously described in
DOCA-salt hypertensive rats. Furthermore, this suggests that ET-1 may be
involved in the maintenance of high blood pressure in mineralocorticoid
hypertension.
ARTICLES
Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
Medical Research Council of Canada Multidisciplinary Research Group on Hypertension, University of Montreal, Canada.
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