This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Henry, J. P. Articles by Hendley, E. D. Search for Related Content PubMed PubMed Citation Articles by Henry, J. P. Articles by Hendley, E. D.

Hypertension, Vol 21, 714-723, Copyright © 1993 by American Heart Association

ARTICLES

Psychosocial stress can induce chronic hypertension in normotensive strains of rats

JP Henry, YY Liu, WE Nadra, CG Qian, P Mormede, V Lemaire, D Ely and ED Hendley
Drew/UCLA Hypertension Research Center, Charles R. Drew University of Medicine and Science 90059.

We report on five 6-month experiments during which five colonies of four male and four female rats were exposed to psychosocial stress. Monthly blood pressure measurements by a tail-cuff method showed a modest (10 mm Hg) increase in two studies using Sprague-Dawley rats. In two further studies using the more aggressive Long-Evans strain, terminal direct carotid arterial pressures were taken as well, and in one study the differences exceeded 20 mm Hg. A fifth study used the Wistar-Kyoto, hyperactive (WKHA) strain developed by Hendley, and no differences were observed. Heart and adrenal weights; adrenal catecholamine synthetic enzymes; and heart, aortic, and kidney histology were measured and showed significant changes, which for the most part paralleled blood pressure changes. Social instability and the associated blood pressure changes were made more severe by periodic mixing of males from different colonies. This had no effect on the peaceable WKHA rats, some effect on the Sprague-Dawley rats, and a severe effect on the Long-Evans rats. The WKHA rats failed to show blood pressure changes despite stress-induced increases in heart and adrenal weights. Thus, different types of psychosocial stress and different genetics combine to induce a variety of neuroendocrine changes, not all of which necessarily lead to increased blood pressure.

This article has been cited by other articles:

				U. Saleem, M. Khaleghi, N. G. Morgenthaler, A. Bergmann, J. Struck, T. H. Mosley Jr., and I. J. Kullo Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2558 - 2564. [Abstract] [Full Text] [PDF]

				M. S. Weinberg, A. P. Bhatt, M. Girotti, C. V. Masini, H. E. W. Day, S. Campeau, and R. L. Spencer Repeated Ferret Odor Exposure Induces Different Temporal Patterns of Same-Stressor Habituation and Novel-Stressor Sensitization in Both Hypothalamic-Pituitary-Adrenal Axis Activity and Forebrain c-fos Expression in the Rat Endocrinology, February 1, 2009; 150(2): 749 - 761. [Abstract] [Full Text] [PDF]

				W. Zhang, T. Sakurai, Y. Fukuda, and T. Kuwaki Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1654 - R1663. [Abstract] [Full Text] [PDF]

				T. Costoli, A. Bartolomucci, G. Graiani, D. Stilli, G. Laviola, and A. Sgoifo Effects of chronic psychosocial stress on cardiac autonomic responsiveness and myocardial structure in mice Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2133 - H2140. [Abstract] [Full Text] [PDF]

				I. Bernatova, M. P. Key, J. B. Lucot, and M. Morris Circadian Differences in Stress-Induced Pressor Reactivity in Mice Hypertension, November 1, 2002; 40(5): 768 - 773. [Abstract] [Full Text] [PDF]

				K. A Alkadhi, S. A Otoom, F. L Tanner, D. Sockwell, and Y. H Hogan Inhibition of Ganglionic Long-Term Potentiation Decreases Blood Pressure in Spontaneously Hypertensive Rats Experimental Biology and Medicine, December 1, 2001; 226(11): 1024 - 1030. [Abstract] [Full Text] [PDF]

				A. Caplea, D. Seachrist, G. Dunphy, and D. Ely Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1793 - H1801. [Abstract] [Full Text] [PDF]

				A. Caplea, D. Seachrist, G. Dunphy, and D. Ely SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H58 - H66. [Abstract] [Full Text] [PDF]

				D. A. Scheuer and S. W. Mifflin Repeated intermittent stress exacerbates myocardial ischemia-reperfusion injury Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R470 - R475. [Abstract] [Full Text] [PDF]