Hypertension, Vol 22, 380-387, Copyright © 1993 by American Heart Association
JF Arnal, AI el Amrani, G Chatellier, J Menard and JB Michel
Wistar rats given a nitric oxide synthase inhibitor, NG-nitro-L-
arginine-methyl ester (L-NAME), for 4 weeks develop time- and dose-
dependent hypertension without cardiac hypertrophy. This initial study of
the relation between left ventricular weight and L-NAME-induced
hypertension has now been extended by giving 50 mg/kg per day L-NAME to
Wistar rats (n = 30) for 8 weeks and comparing results with those from
control rats (n = 10) and two-kidney, one clip rats (n = 14). Although
L-NAME rats and two-kidney, one clip rats had increased systolic blood
pressures during the last 3 weeks of the experiment (202 +/- 24 and 224 +/-
16 mm Hg, respectively), the ratio of left ventricular weight to body
weight of L-NAME rats (2.12 +/- 0.32 mg/g) was not statistically different
from that of control rats (1.93 +/- 0.13 mg/g), whereas that of two-kidney,
one clip rats was increased (2.85 +/- 0.20 mg/g). The plasma renin activity
of L-NAME rats was not significantly different from that of control rats.
Two L-NAME rat subgroups were defined according to the presence of left
ventricular hypertrophy (ratio of left ventricular weight to body weight
> 2.19 mg/g, control mean +2 SD) (6 of 25) or its absence (19 of 25).
Systolic blood pressure, plasma renin activity, and cardiac angiotensin
converting enzyme activity of L- NAME rats with left ventricular
hypertrophy were significantly higher than those of the subgroup
without.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Cardiac weight in hypertension induced by nitric oxide synthase blockade
INSERM Unit 367, Paris, France.
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