This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bednarik, J. A. Articles by May, C. N. Search for Related Content PubMed PubMed Citation Articles by Bednarik, J. A. Articles by May, C. N. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

Hypertension, Vol 24, 49-55, Copyright © 1994 by American Heart Association

ARTICLES

Differential regional hemodynamic effects of corticotropin in conscious sheep

JA Bednarik and CN May
Howard Florey Institute of Physiology and Medicine, University of Melbourne, Parkville, Australia.

The regional hemodynamic effects of 5 days of intravenous infusion of corticotropin (ACTH) (5 micrograms/kg per day) were examined in conscious sheep (n = 8). Mean arterial pressure increased from 81 +/- 2 to 93 +/- 3 mm Hg (P < .001) on day 2 of ACTH and remained at this level during the infusion. Cardiac output increased from 5.13 +/- 0.19 to 6.06 +/- 0.33 L/min (P < .01) because of an increase in stroke volume from 65 +/- 4 to 79 +/- 8 mL per beat (P < .01); heart rate remained unchanged. ACTH did not alter total peripheral conductance but had differential effects on regional conductances. Mesenteric conductance fell from 5.8 +/- 0.2 to a minimum of 4.9 +/- 0.3 (mL/min)/mm Hg (P < .05), and renal conductance increased from 3.5 +/- 0.3 to 4.6 +/- 0.3 (mL/min)/mm Hg (P < .001). There was a small increase in iliac conductance (P < .05) and no change in coronary conductance. Mesenteric and iliac conductances fell progressively over 24 to 48 hours, whereas renal conductance increased rapidly after 3 hours of ACTH, reaching a maximum after 6 hours. Renal blood flow was increased during ACTH infusion from 278 +/- 18 to 403 +/- 23 mL/min (P < .001); mesenteric blood flow was unchanged; there was a small increase in iliac blood flow (P < .01); and coronary blood flow increased (P < .05), paralleling the change in cardiac output.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				A. M.D. Watson, G. W. Lambert, K. J. Smith, and C. N. May Urotensin II Acts Centrally to Increase Epinephrine and ACTH Release and Cause Potent Inotropic and Chronotropic Actions Hypertension, September 1, 2003; 42(3): 373 - 379. [Abstract] [Full Text] [PDF]

				C. N. May and J. A. Bednarik Regional Hemodynamic and Endocrine Effects of Aldosterone and Cortisol in Conscious Sheep : Comparison With the Effects of Corticotropin Hypertension, August 1, 1995; 26(2): 294 - 300. [Abstract] [Full Text]