(Hypertension. 1995;25:166-169.)
© 1995 American Heart Association, Inc.
Articles |
A Heme Oxygenase Product, Presumably Carbon Monoxide, Mediates a Vasodepressor Function in Rats
From the Department of Pharmacology, New York Medical College, Valhalla, and The Rockefeller University (N.G.A.), New York City.
Correspondence to Robert A. Johnson, PhD, Department of Pharmacology, New York Medical College, Valhalla, NY 10595.
Abstract Heme oxygenase is a mammalian enzyme that
converts heme to biliverdin and carbon monoxide. Carbon monoxide
activates soluble guanylate cyclase and relaxes vascular smooth muscle,
and it has been implicated as a potential neuromessenger. The
regulatory functions of endogenous carbon monoxide on hemodynamics are
not known. Zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG) inhibits heme
oxygenase in rats and thus permits assessment of the hemodynamic
response to inhibition of endogenous carbon monoxide synthesis. In
chronically instrumented, awake male Sprague-Dawley rats,
ZnDPBG (45 µmol/kg IP) increased mean arterial pressure (19±2%,
P<.05) and total peripheral resistance (47±4%,
P<.05), decreased cardiac output (-16±2%,
P<.05), but did not affect heart rate. Another heme
oxygenase inhibitor, zinc protoporphyrin IX (45 µmol/kg IP), also
increased arterial pressure (17±5%, P<.05), with no
effect on heart rate. In contrast, neither the nonmetallic
deuteroporphyrin 2,4-bis glycol (45 µmol/kg IP) nor biliverdin (45
µmol/kg IP) had any effect on blood pressure or heart rate. These
findings suggest that ZnDPBG and zinc protoporphyrin IX increase
arterial pressure by inhibiting heme oxygenase activity. After
pretreatment with chlorisondamine (5 mg/kg IP) or prazosin (5 mg/kg IP)
to inhibit autonomic ganglionic or 
1-adrenoceptor
functions, respectively, ZnDPBG did not affect arterial pressure or
heart rate. This suggests that ZnDPBG-induced increases in blood
pressure rely on autonomic nervous function. We conclude that the
pressor response to heme oxygenase inhibitors results from withdrawal
of the inhibitory influence of endogenous carbon monoxide on a pressor
mechanism mediated by the autonomic nervous system.
Key Words: blood pressure • carbon monoxide • heme oxygenase • autonomic nervous system
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|
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|
|
|
|
 |
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 R. Motterlini, A. Gonzales, R. Foresti, J. E. Clark, C. J. Green, and R. M. Winslow Heme Oxygenase-1–Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo Circ. Res., September 7, 1998; 83(5): 568 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
A. Chlorakos, B. L. Langille, and S. L. Adamson Cardiovascular responses attenuate with repeated NO synthesis inhibition in conscious fetal sheep Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1472 - H1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Johnson, E. Colombari, D. S. A. Colombari, M. Lavesa, W. T. Talman, and A. Nasjletti Role of Endogenous Carbon Monoxide in Central Regulation of Arterial Pressure Hypertension, October 1, 1997; 30(4): 962 - 967. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
M. Hausberg and V. K. Somers Neural Circulatory Responses to Carbon Monoxide in Healthy Humans Hypertension, May 1, 1997; 29(5): 1114 - 1118. [Abstract] [Full Text]
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|
|
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|
|
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N. Ishizaka and K. K. Griendling Heme Oxygenase-1 Is Regulated by Angiotensin II in Rat Vascular Smooth Muscle Cells Hypertension, March 1, 1997; 29(3): 790 - 795. [Abstract] [Full Text]
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|
|
|
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|
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