(Hypertension. 1995;25:408-414.)
© 1995 American Heart Association, Inc.
Articles |
Role of Nitric Oxide on Papillary Blood Flow and Pressure Natriuresis
From the Departamento de Fisiología y Farmacología, Facultad de Medicina, Murcia, Spain.
Correspondence to Francisco J. Fenoy, Departamento de Fisiología y Farmacología, Facultad de Medicina, 30100-Murcia, Spain.
Abstract This study examined whether nitric oxide synthesis
blockade or potentiation (with
N
-nitro-L-arginine methyl ester
[L-NAME] or N-acetylcysteine, respectively) can shift the
relations between sodium excretion, papillary blood flow, and renal
perfusion pressure. Papillary blood flow was measured by laser Doppler
flowmetry. A low dose of L-NAME (3.7 nmol/kg per minute) reduced
papillary blood flow only at high arterial pressure (140 mm Hg), but
it had no effect on pressure natriuresis. Infusion of 37 nmol/kg per
minute L-NAME reduced cortical blood flow by 9% at all perfusion
pressures studied, lowered papillary blood flow by 8% and 19% at 120
and 140 mm Hg, respectively, and blunted the pressure-natriuresis
response. The administration of 185 nmol/kg per minute L-NAME reduced
cortical blood flow by 30% and decreased papillary blood flow by 25%
in the range of 100 to 140 mm Hg of arterial pressure. Blockade of
nitric oxide synthesis with L-NAME at all doses studied reduced
papillary blood flow only at high renal perfusion pressures, but
papillary blood flow remained essentially unchanged at low perfusion
pressures, thus restoring papillary blood flow autoregulation.
N-Acetylcysteine (1.8 mmol/kg) increased papillary blood
flow by 9% and shifted the relations between papillary blood flow,
sodium excretion, and renal perfusion pressure toward lower pressures.
This effect of N-acetylcysteine on papillary blood flow was
blocked by subsequent L-NAME administration. The results indicate that
increases in renal medullary levels of nitric oxide as renal perfusion
pressure rises may be responsible for the lack of renal medullary blood
flow autoregulation and the pressure-natriuretic response in
volume-expanded rats.
Key Words: nitric oxide • kidney medulla • kidney • renal circulation • laser-Doppler flowmetry
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